Results 61 to 70 of about 1,223,173 (297)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Shift of percolation thresholds for epidemic spread between static and dynamic small-world networks

, 2010
The aim of the study was to compare the epidemic spread on static and dynamic small-world networks. The network was constructed as a 2-dimensional Watts-Strogatz model (500x500 square lattice with additional shortcuts), and the dynamics involved rewiring
A.J. Stacey, B. Dybiec, C. Dye, D.J. Watts, E. Volz, G.P. Garnett, J. K. Ochab, J. Saramäki, J. Swinton, J.M. Read, M.E.J. Newman, M.E.J. Newman, M.J. Keeling, P. F. Góra, P. Grassberger, R.M. May, T. Gross   +16 more
core   +2 more sources

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source

Comment on ''Properties of highly clustered networks" [PDF]

, 2008
We consider a procedure for generating clustered networks previously reported by Newman [Phys. Rev. E 68, 026121 (2003)]. In the same study, clustered networks generated according to the proposed model have been reported to have a lower epidemic ...
Darren M. Green, Istvan Z. Kiss, O. Diekman   +2 more
core   +2 more sources

Epidemic vomiting [PDF]

Journal of Hygiene, 1974
Two outbreaks of epidemic vomiting are described. One affected 107 students and staff at a college of education out of a total of 398 persons. The other affected 172 pupils and staff out of 357 at a secondary school. Evidence is presented that in both cases infection was acquired in the dining hall of the institution concerned but no specific item of ...
openaire   +2 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Integration of a social network strategy into index testing to increase HIV case finding among Haitian migrants and their descendants in the Dominican Republic

BMC Infectious Diseases
Introduction Increasing effectiveness, efficiency, and reach of HIV case-finding strategies among priority populations is essential for epidemic control.
Caterina Casalini, Molly Goggin-Kehm, Jacob Michel, Roudy Joseph, Ruth Diaz, Gianmarco Martinez, Stevenson Saint-Hilaire, Gercy Mateo, Chris Akolo, Navindra Persaud, Natasha Mack, Katherine Hernandez, Mario Reyes, Ceida Martinez, Leidy Tamarez, Mayra Elizardi, Maria Garcia, Algeni Lorenzo, Johana Molil, Elvis Baez, Rebecca Fertziger, Alejandro Soto   +21 more
doaj   +1 more source

The end time of SIS epidemics driven by random walks on edge-transitive graphs [PDF]

, 2019
Network epidemics is a ubiquitous model that can represent different phenomena and finds applications in various domains. Among its various characteristics, a fundamental question concerns the time when an epidemic stops propagating.
Figueiredo, Daniel, Iacobelli, Giulio, Shneer, Seva   +2 more
core   +2 more sources

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

Fast-Tracking Vaccine Manufacturing: CEPI’s Rapid Response Framework for the 100 Days Mission

Vaccines
CEPI (the Coalition for Epidemic Preparedness Innovation)’s CMC rapid response framework is developed to support accelerated vaccine development, manufacturing, and roll-out for various outbreak scenarios to achieve the 100 Days Mission.
June Kim, Ramin Sabet-Azad, Dimki Patel, Gene Malin, Syed Hassan Askary, Anna Särnefält   +5 more
doaj   +1 more source