Results 61 to 70 of about 5,214,788 (302)

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
Annemarie Samalecos, Annemarie Samalecos (275635), Anja Wolf (275636), Weimar, C.H., Philipp Velicky, Michelle Kruse (275634), Wolf Anja, Kruse Michelle, Nick S Macklon, Macklon Nick S., Charlotte H. E. Weimar (148304), Nick S. Macklon (148320), Velicky Philipp, Weimar Charlotte H. E., Maren Schwenke, Philipp Velicky (275632), Gellersen Birgit, Schwenke, M., Maren Schwenke (275628), Knöfler Martin, Schwenke Maren, Gellersen, B., Samalecos Annemarie, Wolf, A., Bamberger, A.M., Martin Knöfler, Anja Wolf, Bamberger Ana-Maria, Michelle Kruse, Charlotte H E Weimar, Birgit Gellersen (148307), Velicky, P., Ana-Maria Bamberger, Ana-Maria Bamberger (275637), Kruse, M., Macklon, N.S., Birgit Gellersen, Knofler, M., Samalecos, A., Martin Knöfler (275630)   +39 more
core   +1 more source

Zinc flux in skin: Identity and function of metallothionein 1–positive cells in skin homeostasis

JID Innovations
Zinc is essential for skin homeostasis, yet the identity and function of zinc-rich epidermal cells remain poorly defined. MT1 (metallothionein-1), a zinc-responsive protein, is commonly used as an intracellular zinc marker, but whether MT1+ cells ...
Sofia Brito, Jeong-Yun Kim, Sung Kweon Cho, Gwangbin Lee, Ji-Hwan Park, Jiyoon Kim, Bum-Ho Bin   +6 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Mechanotransduction in epidermal Merkel cells [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
The cellular and molecular basis of vertebrate touch reception remains least understood among the traditional five senses. Somatosensory afferents that innervate the skin encode distinct tactile qualities, such as flutter, slip, and pressure. Gentle touch is thought to be transduced by somatosensory afferents whose tactile end organs selectively filter
Masashi, Nakatani, Srdjan, Maksimovic, Yoshichika, Baba, Ellen A, Lumpkin   +3 more
openaire   +2 more sources

Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis. [PDF]

PLoS ONE, 2013
During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis.
Sha Wang, Sang-Wook Cha, Aaron M Zorn, Christopher Wylie   +3 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Comprehensive Transcriptional Profiling of Human Epidermis, Reconstituted Epidermal Equivalents, and Cultured Keratinocytes Using DNA Microarray Chips

, 2009
Because of its accessibility, skin has been among the first organs analyzed using DNA microarrays; psoriasis, melanomas, carcinomas, chronic wound biopsies, and epidermal keratinocytes in culture have been intensely investigated.
Miroslav Blumenberg, Blumenberg, Miroslav, Zavadil, Jiri, Lee, Ding-Dar, Marjana Tomic-Canic, Tomic-Canic, Marjana, Jiri Zavadil, Ding-Dar Lee   +7 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

GRHL2 regulates keratinocyte EMT-MET dynamics and scar formation during cutaneous wound healing

Cell Death and Disease
After cutaneous wounds successfully heal, keratinocytes that underwent the epithelial-mesenchymal transition (EMT) regain their epithelial characteristics, while in scar tissue, epidermal cells persist in a mesenchymal state.
Tianying Chen, Bo Zhang, Hanqi Xie, Chenyu Huang, Qiong Wu   +4 more
doaj   +1 more source