Results 51 to 60 of about 430,801 (304)

Par6b regulates the dynamics of apicobasal polarity during development of the stratified Xenopus epidermis. [PDF]

PLoS ONE, 2013
During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis.
Sha Wang, Sang-Wook Cha, Aaron M Zorn, Christopher Wylie   +3 more
doaj   +1 more source

Epidermal Stem Cells of the Skin [PDF]

Annual Review of Cell and Developmental Biology, 2006
The skin constantly renews itself throughout adult life, and the hair follicle undergoes a perpetual cycle of growth and degeneration. Stem cells (SCs) residing in the epidermis and hair follicle ensure the maintenance of adult skin homeostasis and hair regeneration, but they also participate in the repair of the epidermis after injuries. We summarize
Blanpain, Cédric, Fuchs, Elaine
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]

, 2010
Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Mazur Pawel K., Radtke, Freddy, Freddy Radtke, Roland M Schmid, Schmid, Roland M., Nakhai Hassan, Grüner, Barbara M., Pawel K Mazur, Schmid Roland M., Barbara M. Grüner, Bence Sipos, Nakhai, Hassan, Jens T Siveke, Strobl Lothar J., Siveke, J.T., Mazur, P.K., Radtke Freddy, Sipos, Bence, Radtke, F., Barbara M Grüner, Zimber-Strobl Ursula, Nakhai, H., Jens T. Siveke, Sipos, B., Grüner, B.M., Schmid, R.M., Strobl, Lothar J., Grüner Barbara M., Strobl, L.J., Lothar J Strobl, Lothar J. Strobl, Zimber-Strobl, Ursula, Hassan Nakhai, Pawel K. Mazur, Roland M. Schmid, Mazur, Pawel K., Ursula Zimber-Strobl, Sipos Bence, Siveke Jens T., Zimber-Strobl, U., Siveke, Jens T.   +40 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Caracterização do folículo piloso como nicho de células progenitoras neurais e epidermais em camundongos [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2011Células tronco são células com capacidade de auto renovação, e de ...
Pereira, Ricardo Mueller Cesario
core  

Comprehensive Transcriptional Profiling of Human Epidermis, Reconstituted Epidermal Equivalents, and Cultured Keratinocytes Using DNA Microarray Chips

, 2009
Because of its accessibility, skin has been among the first organs analyzed using DNA microarrays; psoriasis, melanomas, carcinomas, chronic wound biopsies, and epidermal keratinocytes in culture have been intensely investigated.
Miroslav Blumenberg, Blumenberg, Miroslav, Zavadil, Jiri, Lee, Ding-Dar, Marjana Tomic-Canic, Tomic-Canic, Marjana, Jiri Zavadil, Ding-Dar Lee   +7 more
core   +1 more source

Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa

Cell Reports, 2019
Summary: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown.
Laura De Rosa, Alessia Secone Seconetti, Giorgio De Santis, Giovanni Pellacani, Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Graziella Pellegrini, Johann W. Bauer, Michele De Luca   +9 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source