Involucrin in the Epidermal Cells of Subprimates.
Journal of Investigative Dermatology, 1989 The protein involucrin is a precursor of the cross-linked envelope that forms during terminal differentiation of the keratinocyte. Most of the human involucrin molecule consists of a segment of homologous repeats of a sequence of 10 amino acids. A similar segment is present in the involucrin of other higher primates, but not in lower animals.
Simon, Marcia, Green, Howard
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AQP5 regulates the proliferation and differentiation of epidermal stem cells in skin aging [PDF]
Brazilian Journal of Medical and Biological Research, 2020 The epidermis, the outermost layer of the skin, is the first barrier that comes into contact with the external environment. It plays an important role in resisting the invasion of harmful substances and microbial infections. The skin changes with age and
Jing Zhou +5 more
doaj +2 more sources
Conjunctival reconstruction with progenitor cell-derived autologous epidermal sheets in rhesus monkey. [PDF]
PLoS ONE, 2011 Severe ocular surface diseases are some of the most challenging problems that the clinician faces today. Conventional management is generally unsatisfactory, and the long-term ocular consequences of these conditions are devastating.
Rong Lu +6 more
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Analysis of the mechanisms of resistance to Epidermal growth factor receptor inhibitors and development of multiple targeted strategies [PDF]
, 2008 Background. Primary and acquired resistance to selective Epidermal growth factor receptor (EGFR) inhibitors remains the most significant obstacle to the success of these targeted agents in cancer therapy.
Rosa, Roberta
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Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes [PDF]
, 2011 This work was supported by a project grant from the Biotechnology and Biological Sciences Research Council, UKBreast Tumor Kinase (Brk/PTK6) has a relatively limited expression profile in normal tissue.
Tupper, J +5 more
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Stem Cell Research & Therapy, 2022 Background Efficient re-epithelialization is important for successful skin wound healing. The proportion of epidermal stem cells (EpSCs) and dendritic epidermal T cells (DETCs) determines the extent of wound re-epithelialization, especially in large ...
Mian Liu +14 more
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Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]
, 2003 Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi +5 more
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Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation [PDF]
, 2011 PMCID: PMC3206954This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Connelly, JT +18 more
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Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. [PDF]
PLoS ONE, 2013 After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epidermis
Rachel A Patterson +5 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source