Results 31 to 40 of about 430,801 (304)

Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. [PDF]

PLoS ONE, 2013
After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epidermis
Rachel A Patterson, Michelle T Juarez, Anita Hermann, Roman Sasik, Gary Hardiman, William McGinnis   +5 more
doaj   +1 more source

Dynamic shifts in chromatin states differentially mark the proliferative basal cells and terminally differentiated cells of the developing epidermis

Epigenetics, 2020
Post-translational modifications on nucleosomal histones represent a key epigenetic regulatory mechanism to mediate the complex gene expression, DNA replication, and cell cycle changes that occur in embryonic cells undergoing lineage specification ...
Yan Ting Shue, Kang Ting Lee, Benjamin William Walters, Hui Binn Ong, Shaktheeshwari Silvaraju, Wei Jun Lam, Chin Yan Lim   +6 more
doaj   +1 more source

The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model

, 2012
One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence
Arnoldner, Christoph, Geißler, Christin, Eckardt, Anne Gisela, Hambek, Markus, Wagenblast, Jens, Diensthuber, Marc, Stöver, Timo   +6 more
core   +1 more source

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

EMBO Molecular Medicine, 2019
Psoriasis is a common inflammatory skin disease involving a cross‐talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF‐SCs) in psoriasis is not well defined.
Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner   +6 more
doaj   +1 more source

Hair follicle epidermal stem cells define a niche for tactile sensation

eLife, 2018
The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive.
Chun-Chun Cheng, Ko Tsutsui, Toru Taguchi, Noriko Sanzen, Asako Nakagawa, Kisa Kakiguchi, Shigenobu Yonemura, Chiharu Tanegashima, Sean D Keeley, Hiroshi Kiyonari, Yasuhide Furuta, Yasuko Tomono, Fiona M Watt, Hironobu Fujiwara   +13 more
doaj   +1 more source

Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]

, 2002
The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Holíkova, Zuzana, Kaltner, Herbert, Motlik, Jan, Gabius, Hans-Joachim, Plzák, Jan, Smetana, Karel, Hercogová, Jana, Dvorankova, Barbora   +7 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Hair follicle germinative epidermal cells: a molecular study [PDF]

, 1999
At the base of the hair follicle epidermal matrix is a population of germinative epidermal (GE) cells that is in close communication with the dermal papilla.
Whitehouse, C.J., Whitehouse, Claire Jenna   +1 more
core  

Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)

, 2004
Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing.
Mansour Mohamadzadeh, Brammer, Melissa, Luftig, Ronald B., Sestak, Karol, Melissa Brammer, Karol Sestak, Ronald B Luftig, Mohamadzadeh, Hamid, Hamid Mohamadzadeh, Mohamadzadeh, Mansour   +9 more
core   +1 more source

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker, Kirkwood, L.A., Lisa A Kirkwood, Dawn C. Walker, Georgopoulos, N.T., Lisa A. Kirkwood, Kirkwood Lisa A., Jennifer Southgate, Georgopoulos, Nikolaos T., Walker, Dawn C., Walker, D.C., Georgopoulos Nikolaos T., Nikolaos T. Georgopoulos, Kirkwood, Lisa A., Southgate, Jennifer, Southgate, J., Southgate Jennifer, Nikolaos T Georgopoulos, Walker Dawn C.   +18 more
core   +1 more source