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Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor
Biochemistry, 1996The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
J M, Sherrill, J, Kyte
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Epidermal Growth Factor Receptor Mutations
Thoracic Surgery Clinics, 2020Up to 20% of lung adenocarcinomas in the United States and Europe and 50% in Asia have activating mutations of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). The identification and subsequent targeting of mutations with EGFR-tyrosine kinase inhibitors (TKIs) led to significant advances in treatment of EGFR-mutant lung cancer.
Erin M, McLoughlin, Ryan D, Gentzler
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Radioimmunoassay of Epidermal Growth Factor
Endocrinology, 1972Epidermal growth factor (EGF) is a biologically active polypeptide extracted from male mouse submaxillary glands. It exists either alone or complexed with an arginine esterase. It causes generalized epidermal growth and keratinization in the immature mouse and results in precocious tooth eruption and eye-opening that are the basis for an EGF bioassay ...
R L, Byyny, D N, Orth, S, Cohen
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Epidermal growth factor in blood
Regulatory Peptides, 1986The presence of receptors for epidermal growth factor (EGF) in a wide variety of human tissues and also some tumours indicates an as yet undefined role for EGF and it is therefore necessary to know precise concentrations in blood and other fluids. We have investigated the occurrence of EGF in the circulation and found that in platelet rich plasma, EGF ...
A P, Savage +3 more
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2013
The epidermal growth factor family includes a number of cytokines inducing the proliferation of epithelial cells. The founding member (EGF) is a small protein containing 53 aminoacids and 3 disulfide bonds inducing the proliferation of cells sharing its receptor (EGFR), a member of the Erb family widely used as target of anti-tumoral biomedicines ...
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The epidermal growth factor family includes a number of cytokines inducing the proliferation of epithelial cells. The founding member (EGF) is a small protein containing 53 aminoacids and 3 disulfide bonds inducing the proliferation of cells sharing its receptor (EGFR), a member of the Erb family widely used as target of anti-tumoral biomedicines ...
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1991
Polypeptide growth factors have attracted considerable interest since the initial description of nerve growth factor (NGF) in 1951 (Levi-Montalcini and Hamburger 1951) and, subsequently, the identification of epidermal growth factor (EGF) in 1962 (Cohen 1962).
R. V. Nardi, A. Guglietta, I. Parikh
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Polypeptide growth factors have attracted considerable interest since the initial description of nerve growth factor (NGF) in 1951 (Levi-Montalcini and Hamburger 1951) and, subsequently, the identification of epidermal growth factor (EGF) in 1962 (Cohen 1962).
R. V. Nardi, A. Guglietta, I. Parikh
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Epidermal Growth Factor and Epidermal Growth Factor Signaling Attenuate Laser-Induced Melanogenesis
Dermatologic Surgery, 2013Epidermal growth factor (EGF) is a peptide that promotes cell growth by binding to its receptor (EGFR) on the cell surface. EGF has been used in cosmetics to whiten the skin and for the prevention of postinflammatory hyperpigmentation (PIH), presumably by accelerating wound healing, but the effects of EGF on melanogenesis are not known, and the ...
Woo Jin, Yun +5 more
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Biochemistry, 1989
Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) compete with each other for binding to the EGF receptor. These two growth factors have similar actions, but there are distinguishable differences in their biological activities. It has never been clear how this one receptor can mediate different responses.
M E, Winkler +3 more
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Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) compete with each other for binding to the EGF receptor. These two growth factors have similar actions, but there are distinguishable differences in their biological activities. It has never been clear how this one receptor can mediate different responses.
M E, Winkler +3 more
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Epidermal growth factor and transforming growth factor α
Baillière's Clinical Endocrinology and Metabolism, 1991I have attempted here to outline the basic biochemical knowledge that we have now secured on the EGF family of proteins. In the future we will learn much more about the differential role of EGF versus TGF-alpha, about the physiological significance of amphiregulin, the newest member of this family, and about the roles of TGF-alpha and amphiregulin in ...
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Epidermal growth factor and transforming growth factor α
British Medical Bulletin, 1989This review describes the discovery and initial characterization of the epidermal growth factors (EGFs) and transforming growth factors alpha (TGF alpha), the biosynthesis and tissue distribution of these molecules and a brief description of the effects of these molecules in culture and animals.
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