Results 351 to 360 of about 822,308 (398)

Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor

Biochemistry, 1996
The binding of epidermal growth factor (EGF) to epidermal growth factor receptor (EGF receptor) induces dimerization of the receptor and activation of its protein tyrosine kinase. Each of these three steps was followed as a function of the concentrations of EGF and of EGF receptor. Binding of EGF was followed by sedimentation of the complex between [3H]
J M, Sherrill, J, Kyte
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Epidermal Growth Factor Receptor

Medicinal chemistry, 2019
G. Patrick
semanticscholar   +2 more sources

The epidermal growth factor receptor family [PDF]

Endocrine-Related Cancer, 2005
The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms. They create an interacting system that has the ability to receive and process information that results in multiple outputs.
Bazley, L.A., Gullick, William J.
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Epidermal Growth Factor Receptor Signal Transactivation

IUBMB Life, 2000
AbstractCross‐communication between heterologous signaling systems and the epidermal growth factor receptor (EGFR) has been shown to be critical for a variety of biological responses: EGFR transactivation when G‐protein‐coupled receptors (GPCRs) are stimulated represents the paradigm of an interreceptor network that is dependent on G‐proteins, kinases,
M, Leserer, A, Gschwind, A, Ullrich
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Epidermal Growth Factor Receptor

1995
Abstract The complete nucleotide sequences have been determined for the human EGFR (GenBank accession No X00588), human c-neu (GenBank accession No X03363), human EGFR B3 (HER3, Genbank accession No M29366) and human EGFR B4 (GenBank accession No L07868). Partial sequence information is available for the mouse and chicken EGFRs (Avivi
F Walker, A W Burgess
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Epidermal growth factor receptor-targeted therapy

The British Journal of Radiology, 2008
High epidermal growth factor receptor (EGFR) expression is a feature of human tumours and is an adverse prognostic factor for radiotherapy outcome. High expression is associated with benefit from accelerated radiotherapy in patients with head and neck squamous cell carcinoma.
West, Catharine, West, Catharine M., Joseph, L., Bhana, S.   +3 more
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Epidermal growth factor receptors in human epidermal tumours

British Journal of Dermatology, 1990
Immunolocalization studies using the strepavidin/biotin peroxidase system were used to identify epidermal growth factor receptors in 10 samples of normal skin, 13 seborrhoeic warts (SW), five lesions of Bowen's disease (BD), 11 solar keratoses (SK), 22 basal cell carcinomas (BCC) and five squamous cell carcinomas (SCC).
M N, Nazmi, P J, Dykes, R, Marks
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Epidermal Growth Factor Receptor and Transformation

Surgery Today, 2002
The action of transforming growth factor peptides is mediated by distinct membrane receptors, which in turn activate a postreceptor signaling mechanism, eventually resulting in a mitogenic response. Such a signaling pathway may be modified by oncogene expression at the receptor or postreceptor levels, as well as by alterations in the levels of ...
Panagiotis, Boulougouris, James B, Elder
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Epidermal growth factor and its receptor

Molecular and Cellular Endocrinology, 1987
Epidermal growth factor (EGF) binds with high affinity and specificity to a single site on the external domain of its transmembrane receptor to activate the tyrosine protein kinase activity of its cytoplasmic portion. The EGF receptor gene is amplified and over-expressed in several human tumors, suggesting that increased concentrations of the proto ...
G N, Gill, P J, Bertics, J B, Santon
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Epidermal growth factor receptor ≠ nerve growth factor

Neurobiology of Aging, 1989
I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating ...
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