Results 71 to 80 of about 975,813 (425)

Epidermal Growth Factor Receptor in Pancreatic Cancer [PDF]

Cancers, 2011
Pancreatic cancer is the fourth leading cause of cancer related death. The difficulty in detecting pancreatic cancer at an early stage, aggressiveness and the lack of effective therapy all contribute to the high mortality. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which is expressed in normal human tissues. It is a member
Melissa Oliveira-Cunha, Ajith K. Siriwardena, William G. Newman   +2 more
openaire   +3 more sources

EGFR (Epidermal Growth Factor Receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020
ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF ...
Hatil, Ayca Circir, Cicek, Esra, Oyken, Merve, Erson-Bensan, A Elif   +3 more
openaire   +3 more sources

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib.

Journal of Clinical Oncology, 2005
PURPOSE Epidermal growth factor receptor (EGFR) mutations have been associated with tumor response to treatment with single-agent EGFR inhibitors in patients with relapsed non-small-cell lung cancer (NSCLC). The implications of EGFR mutations in patients
D. Eberhard, B. Johnson, L. Amler, A. Goddard, Sherry Heldens, R. Herbst, William L. Ince, P. Jänne, T. Januario, David H. Johnson, P. Klein, V. Miller, M. Ostland, D. Ramies, Dragan Sebisanovic, Jeremy Stinson, Yu Zhang, S. Seshagiri, K. Hillan   +18 more
semanticscholar   +1 more source

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid. [PDF]

PLoS ONE, 2017
While all 2-methylene-19-nor analogs of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) tested produce an increase in epidermal thickness in the rhino mouse, only a subset reduce utricle size (comedolysis).
Jamie M Ahrens, James D Jones, Nirca J Nieves, Ann M Mitzey, Hector F DeLuca, Margaret Clagett-Dame   +5 more
doaj   +1 more source

Approaching heterogeneity of human epidermal growth factor receptor 2 in surgical specimens of gastric cancer. [PDF]

, 2012
Summary Gastric cancer shows intratumoral heterogeneity for human epidermal growth factor receptor 2 expression. We evaluated whether the number of tissue blocks analyzed or the antibodies used may influence the immunohistochemical results in gastrectomy
Asioli, Sofia, Botta, Cristina, Chiusa, Luigi, Conti, Luca, Ingravallo, Giuseppe, Maiorano, Eugenio, Maletta, Francesca, Molinaro, Luca, Pecchioni, Carla, Sapino, Anna, Satolli, Maria A., Schena, Marina, Verdun di Cantogno, Ludovica, Viale, Giuseppe   +13 more
core   +1 more source

Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.

Journal of Clinical Oncology, 2004
PURPOSE To evaluate the antitumor activity and toxicity of single-agent cetuximab in patients with chemotherapy-refractory colorectal cancer whose tumors express the epidermal growth factor receptor.
L. Saltz, N. Meropol, P. Loehrer, M. Needle, J. Kopit, R. Mayer   +5 more
semanticscholar   +1 more source

Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis [PDF]

arXiv, 2023
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant data (IPD) from randomised controlled trials (RCTs) are unavailable. Methods: A Bayesian network meta-regression model, combining aggregate data (AD) from RCTs and IPD ...
arxiv  

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Joint Stream: Malignant Region Learning for Breast Cancer Diagnosis [PDF]

Volume 99, January 2025, 106899
Early diagnosis of breast cancer (BC) significantly contributes to reducing the mortality rate worldwide. The detection of different factors and biomarkers such as Estrogen receptor (ER), Progesterone receptor (PR), Human epidermal growth factor receptor 2 (HER2) gene, Histological grade (HG), Auxiliary lymph node (ALN) status, and Molecular subtype ...
arxiv   +1 more source

Epidermal growth factor-induced truncation of the epidermal growth factor receptor

Journal of Biological Chemistry, 1989
NIH-3T3 cells expressing the human epidermal growth factor (EGF) receptor were used in experiments to determine the fate of the EGF receptor in cells continuously exposed to EGF. EGF receptor was immunoprecipitated from cells labeled for 12 h with [35S] methionine in the absence or presence of 10 nM EGF.
openaire   +3 more sources