Results 41 to 50 of about 151,133 (238)

Regeneration and expansion of autologous full‐thickness skin through a self‐propagating autologous skin graft technology

Clinical Case Reports, 2019
New autologous skin regeneration technology yielded full‐thickness skin as evidenced by clinical observation and skin biopsy 5 months after surgery, providing relief for debilitating split‐thickness skin graft contracture in a pediatric burn case.
Charles W. Patterson, Matthew Stark, Silpa Sharma, Gerhard S. Mundinger   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Born With Bristles: New Insights on the Kölliker’s Organs of Octopus Skin

Frontiers in Marine Science, 2021
The entire skin surface of octopus embryos, hatchlings and juveniles bears scattered tufts of tiny chitinous setae within small pockets, from which they can be everted and retracted.
Roger Villanueva, Montserrat Coll-Lladó, Laure Bonnaud-Ponticelli, Sergio A. Carrasco, Oscar Escolar, Fernando Á. Fernández-Álvarez, Fernando Á. Fernández-Álvarez, Ian G. Gleadall, Ian G. Gleadall, Jaruwat Nabhitabhata, Nicolás Ortiz, Carlos Rosas, Pilar Sánchez, Janet R. Voight, Jim Swoger   +14 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Actualización en melanoma incidencia, desarrollo, aspectos biológicos y reporte de caso clínico

Oncología, 2022
El melanoma maligno es una neoplasia originada en los melanocitos que derivan de la cresta neural. La mayoría de estos tumores se desarrollan en la piel en la que los melanocitos se asientan, principalmente a nivel epidérmicos y ocasionalmente en la ...
Gerson Saul Espinoza Vera, María Mercedes Poveda Ayora   +1 more
doaj  

Anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae, Pooideae, Poeae)

Lilloa, 2019
El objetivo del presente estudio fue describir la anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae) presente en áreas naturales de la provincia de Entre Ríos.
María E. Moya, Alberto A. Galussi, Luciano J. Casermeiro, María S. Fontana   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Wild Fruits of Crataegus monogyna Jacq. and Sorbus aria (L.) Crantz: From Traditional Foods to Innovative Sources of Pigments and Antioxidant Ingredients for Food Products

Foods, 2023
Hawthorn (Crataegus monogyna Jacq.) and whitebeam (Sorbus aria (L.) Crantz) are wild species traditionally used as ethnic foods in the Mediterranean area.
Cristina Tamayo-Vives, Patricia García-Herrera, María Cortes Sánchez-Mata, Rosa M. Cámara-Hurtado, María Luisa Pérez-Rodríguez, Laura Aceituno, Manuel Pardo-de-Santayana, María Inês Días, Lillian Barros, Patricia Morales   +9 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source