Results 61 to 70 of about 353,568 (296)

C. elegans Hemidesmosomes Sense Collagen Damage to Trigger Innate Immune Response in the Epidermis [PDF]

, 2023
Yi Zhu, Wenna Li, Yifang Dong, Chujie Xia, Rong Fu   +4 more
openalex   +1 more source

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]

, 2016
Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir, Banning, Antje, Eming, Rüdiger, Exner, Yvonne, Hertl, Michael, Kurrle, Nina, Tikkanen, Ritva, Völlner, Frauke   +7 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Born With Bristles: New Insights on the Kölliker’s Organs of Octopus Skin

Frontiers in Marine Science, 2021
The entire skin surface of octopus embryos, hatchlings and juveniles bears scattered tufts of tiny chitinous setae within small pockets, from which they can be everted and retracted.
Roger Villanueva, Montserrat Coll-Lladó, Laure Bonnaud-Ponticelli, Sergio A. Carrasco, Oscar Escolar, Fernando Á. Fernández-Álvarez, Fernando Á. Fernández-Álvarez, Ian G. Gleadall, Ian G. Gleadall, Jaruwat Nabhitabhata, Nicolás Ortiz, Carlos Rosas, Pilar Sánchez, Janet R. Voight, Jim Swoger   +14 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Actualización en melanoma incidencia, desarrollo, aspectos biológicos y reporte de caso clínico

Oncología, 2022
El melanoma maligno es una neoplasia originada en los melanocitos que derivan de la cresta neural. La mayoría de estos tumores se desarrollan en la piel en la que los melanocitos se asientan, principalmente a nivel epidérmicos y ocasionalmente en la ...
Gerson Saul Espinoza Vera, María Mercedes Poveda Ayora   +1 more
doaj  

Anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae, Pooideae, Poeae)

Lilloa, 2019
El objetivo del presente estudio fue describir la anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae) presente en áreas naturales de la provincia de Entre Ríos.
María E. Moya, Alberto A. Galussi, Luciano J. Casermeiro, María S. Fontana   +3 more
doaj   +1 more source

318 The long non-coding RNA LINC00958 is overexpressed in psoriasis epidermis and induces keratinocyte proliferation [PDF]

, 2022
Lei Luo, L. Pasquali, A. Srivastava, A. Pivarcsi, E. Sonkoly   +4 more
openalex   +1 more source