Results 71 to 80 of about 253,312 (306)

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

eLife, 2015
Neoblasts are an abundant, heterogeneous population of adult stem cells (ASCs) that facilitate the maintenance of planarian tissues and organs, providing a powerful system to study ASC self-renewal and differentiation dynamics.
Kimberly C Tu, Li-Chun Cheng, Hanh TK Vu, Jeffrey J Lange, Sean A McKinney, Chris W Seidel, Alejandro Sánchez Alvarado   +6 more
doaj   +1 more source

A Rapid, Highly Efficient and Economical Method of Agrobacterium-Mediated In planta Transient Transformation in Living Onion Epidermis

PLoS ONE, 2014
Transient transformation is simpler, more efficient and economical in analyzing protein subcellular localization than stable transformation. Fluorescent fusion proteins were often used in transient transformation to follow the in vivo behavior of ...
Ke-dong Xu, Xiaohui Huang, Manman Wu, Yan Wang, Yunxia Chang, Kun Liu, Ju Zhang, Yi Zhang, Fuli Zhang, Liming Yi, Tingting Li, Ruiyue Wang, G. Tan, Chengwei Li   +13 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Basal Keratinocytes Contribute to All Strata of the Adult Zebrafish Epidermis

PLoS ONE, 2014
The epidermis of terrestrial vertebrates is a stratified epithelium and forms an essential protective barrier. It is continually renewed, with dead corneocytes shed from the surface and replaced from a basal keratinocyte stem cell population.
R. Lee, P. Asharani, T. Carney, Ben Hogan   +3 more
semanticscholar   +1 more source

Modelling epidermis homoeostasis and psoriasis pathogenesis [PDF]

Journal of the Royal Society Interface, 2013
We present a computational model to study the spatio-temporal dynamics of epidermis homoeostasis under normal and pathological conditions. The model consists of a population kinetics model of the central transition pathway of keratinocyte proliferation ...
Hong Zhang, Wenhong Hou, L. Henrot, S. Schnebert, M. Dumas, C. Heusele, Jin Yang   +6 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Aryl Hydrocarbon Receptor-Signaling Regulates Early Leishmania major-Induced Cytokine Expression

Frontiers in Immunology, 2019
The early inflammatory skin micromilieu affects resistance in experimental infection with Leishmania major. We pursue the concept that macrophages, which take up parasites during early infection, exert decisive influence on the inflammatory micromilieu ...
Niels-Arne Münck, Niels-Arne Münck, Johannes Roth, Cord Sunderkötter, Cord Sunderkötter, Cord Sunderkötter, Jan Ehrchen   +6 more
doaj   +1 more source

A Gene Regulatory Network for Root Epidermis Cell Differentiation in Arabidopsis

PLoS Genetics, 2012
The root epidermis of Arabidopsis provides an exceptional model for studying the molecular basis of cell fate and differentiation. To obtain a systems-level view of root epidermal cell differentiation, we used a genome-wide transcriptome approach to ...
Angela Bruex, R. Kainkaryam, Y. Wieckowski, Y. Kang, Christine Bernhardt, Yang Xia, Xiaohua Zheng, Jean Y. Wang, M. Lee, P. Benfey, P. Woolf, J. Schiefelbein   +11 more
semanticscholar   +1 more source