Results 11 to 20 of about 39,492 (224)
NeuroprotectionParkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease‐modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity—factors that alter gene expression ...
Ayodeji Johnson Ajibare +2 more
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Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. [PDF]
J Immunol ResBackground Host immune responses, including cytokine production, shape the severity of viral epidemics. Epigenetic mechanisms such as DNA methylation regulate cytokine gene expression and may contribute to immune dysregulation in severe disease. Methods This study analyzed interleukin‐7 (IL‐7), IL‐8, and IL‐10 promoter methylation in 145 COVID‐19 ...
Yulugkural Z +4 more
europepmc +2 more sources
Evolving Lessons on Metazoan Primordial Germ Cells in Diversity and Development. [PDF]
Mol Reprod DevABSTRACT Germ cells are pivotal for the continuation of biological species. The metazoan germline develops from primordial germ cells (PGCs) that undergo multiple rounds of mitotic divisions. The PGCs are specified by either maternal inheritance of asymmetrically polarized cytoplasmic mRNAs/proteins (found in roundworms, flies, fishes, frogs, and fowl)
Bhattacharya I +5 more
europepmc +2 more sources
On the hodological criterion for homology
Frontiers in Neuroscience, 2015 Owen’s pre-evolutionary definition of a homologue as the same organ in different animals under every variety of form and function and its redefinition after Darwin as the same trait in different lineages due to common ancestry entail the same heuristic ...
Macarena eFaunes +4 more
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Neural correlates of epigenesis [PDF]
Proceedings of the National Academy of Sciences, 2006 The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable for depression. We investigated the underlying neural mechanisms of these epigenetic processes in individuals with no history of psychopathology
Turhan, Canli +8 more
openaire +2 more sources
Epigenetics: What it is about? [PDF]
, 2014 Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in
Ogryzko, Vasily, Saade, Evelyne
core +3 more sources
[Reprogramming and epigenesis].
Medecine sciences : M/S, 2005 Les succès récents du clonage animal démontrent que le noyau d’une cellule somatique adulte différenciée peut retourner à un état de type embryonnaire, lui permettant de repasser par les étapes qui conduisent à la naissance d’un animal viable et normal.
Beaujean, Nathalie +3 more
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Мінеральні ресурси УкраїниAuthigenic carbonate minerals, together with clayey matter, play a leading role in the cementation of terrigenous phaneromorphic (granular) rocks. Studying the regularities of carbonate authigenesis is of primary importance for oil and gas geology.
O. Yu. Lukin, I. P. Gafych, Ya. V. Lukin
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The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution [PDF]
, 2018 Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual ...
Blancke, Stefaan +2 more
core +3 more sources
Altered expression of DNMT3A gene in B-cell acute lymphoblastic leukemia by mercaptopurine
فصلنامه دانشگاه علوم پزشکی جهرم, 2021 Introduction: Current medications used for acute lymphoblastic leukemia (ALL) such as mercaptopurine target molecular factors involved in its onset and progression including DNA methyltransferases (DNMTs) because these enzymes are implicated in ...
Seyedhossein Hekmatimoghaddam +4 more
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