Results 171 to 180 of about 486,968 (249)

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer. [PDF]

Nat Commun
Williams AM, Phillips NS, Dong Q, Ehrhardt MJ, Gilmore N, Loh KP, Meng X, Ness KK, Hudson MM, Robison LL, Wang Z, Krull KR.   +11 more
europepmc   +1 more source

Alternative Epigenetic Chromatin States of Polycomb Target Genes

, 2010
Yuri B. Schwartz, Tatyana G. Kahn, Per Stenberg, Katsuhito Ohno, Richard Bourgon, Vincenzo Pirrotta   +5 more
openalex   +2 more sources

Epigenetic Metabolite Acetate Inhibits Class I/II Histone Deacetylases, Promotes Histone Acetylation, and Increases HIV-1 Integration in CD4⁺T Cells [PDF]

, 2017
Jean-François Bolduc, Laurent Hany, Corinne Barat, Michel Ouellet, Michel J. Tremblay   +4 more
openalex   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Epigenetic Regulation of Salt Stress Responses in Rice: Mechanisms and Prospects for Enhancing Tolerance. [PDF]

Epigenomes
Talarico E, Greco E, Guarasci F, Araniti F, Chiappetta A, Bruno L.   +5 more
europepmc   +1 more source

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance

Advanced Science, EarlyView.
β‐glucan‐induced trained immunity reprograms macrophages toward hyperinflammation, exacerbating inflammatory arthritis. In a collagen‐induced arthritis model, trained macrophages intensify disease severity and confer ferroptosis resistance in synovial cells via IL‐1β/NAT10‐mediated FSP1 mRNA modification.
Haibo Su, Baoying Zhang, Qiudi Deng, Jiaxin Huang, Jinyu Feng, Yuan Fu, Yuejun Huang, Weikun Deng, YingJun Su, Huisheng Liu, Ning‐yi Shao, Zhenhui Zhang, Jianwei Dai   +12 more
wiley   +1 more source

Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses. [PDF]

J Gerontol B Psychol Sci Soc Sci
Li DL, Xu X, Hodge AM, Southey MC, Giles GG, Milne RL, Dugué PA.   +6 more
europepmc   +1 more source

Epigenetic Aging: More Than Just a Clock When It Comes to Cancer

, 2019
Ming Yu, William D. Hazelton, E. Georg Luebeck, William M. Grady   +3 more
openalex   +2 more sources

Nitric Oxide and KLF4 Protein Epigenetically Modify Class II Transactivator to Repress Major Histocompatibility Complex II Expression during Mycobacterium bovis Bacillus Calmette-Guérin Infection [PDF]

, 2013
Devram Sampat Ghorpade, Sahana Holla, Akhauri Yash Sinha, Senthilkumar Alagesan, Kithiganahalli Narayanaswamy Balaji   +4 more
openalex   +1 more source