Results 11 to 20 of about 486,968 (249)

Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty

Scientific Reports, 2023
The genetic material encoded on X and Y chromosomes provides the foundation by which biological sex differences are established. Epigenetic regulators expressed on these sex chromosomes, including Kdm6a (Utx), Kdm5c, and Ddx3x have far-reaching impacts ...
Kylie D. Rock, Lillian M. Folts, Hannah C. Zierden, Ruth Marx-Rattner, Nicolae Adrian Leu, Bridget M. Nugent, Tracy L. Bale   +6 more
doaj   +1 more source

Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer

Non-Coding RNA, 2022
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery.
Silvia Di Agostino, Mahrou Vahabi, Chiara Turco, Giulia Fontemaggi   +3 more
doaj   +1 more source

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source

HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception

Scientific Reports, 2023
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of specificity in transmitting signals and cargo to coordinate local and distant cellular functions.
Christopher P. Morgan, Victoria E. Meadows, Ruth Marx-Rattner, Yasmine M. Cisse, Tracy L. Bale   +4 more
doaj   +1 more source

Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein

Molecules, 2021
Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked to the development of acute leukemias characterized by the MLL (mixed-lineage leukemia ...
Corentin Bon, Yang Si, Melanie Pernak, Magdalena Barbachowska, Eva Levi-Acobas, Veronique Cadet Daniel, Corinne Jallet, Dusan Ruzic, Nemanja Djokovic, Teodora Djikić, Katarina Nikolic, Ludovic Halby, Paola B. Arimondo   +12 more
doaj   +1 more source

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

Nature Communications, 2016
Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is ...
David Cano-Rodriguez, Rutger A F. Gjaltema, Laura J Jilderda, Pytrick Jellema, Jelleke Dokter-Fokkens, Marcel H J. Ruiters, Marianne G Rots   +6 more
doaj   +1 more source

Direct Synthesis of Allyl Amines with 2‐Nitrosulfonamide Derivatives via the Tsuji‐Trost Reaction

ChemistryOpen, 2021
The Tsuji‐Trost Reaction is a palladium‐catalysed allylation of nucleophiles that consists in the reaction of a nitrogen, carbon or oxygen‐based nucleophiles with an allylic substrate bearing a leaving group. Here we present the use of 2‐nitrosulfonamide
Corentin Bon, Dr. Paola B. Arimondo, Dr. Ludovic Halby   +2 more
doaj   +1 more source

Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network

Cells, 2022
Absence of the Fragile X Messenger Ribonucleoprotein 1 (FMRP) causes autism spectrum disorders and intellectual disability, commonly referred to as the Fragile X syndrome.
Claudio D’Incal, Jitse Broos, Thierry Torfs, R. Frank Kooy, Wim Vanden Berghe   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

rDNA Clusters Make Contact with Genes that Are Involved in Differentiation and Cancer and Change Contacts after Heat Shock Treatment

Cells, 2019
Human rDNA clusters form numerous contacts with different chromosomal regions as evidenced by chromosome conformation capture data. Heterochromatization of rDNA genes leads to heterochromatization in different chromosomal regions coupled with the ...
Nickolai A. Tchurikov, Daria M. Fedoseeva, Elena S. Klushevskaya, Ivan Y. Slovohotov, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +6 more
doaj   +1 more source