Results 31 to 40 of about 625,174 (305)

Unraveling the epigenetic code in cancer cell-tumor microenvironment crosstalk. [PDF]

Mol Oncol
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Park JH, Kim MY.
europepmc   +2 more sources

Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression [PDF]

, 2014
Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes
de Las Heras, Jose Ignacio, Xenophontos, Maria, Stancheva, Irina, Bao, Xun X., Clouaire, Thomas, Kemp, Sadie E., Gordon, Katrina   +6 more
core   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer

Non-Coding RNA, 2022
Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery.
Silvia Di Agostino, Mahrou Vahabi, Chiara Turco, Giulia Fontemaggi   +3 more
doaj   +1 more source

Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML [PDF]

Frontiers in Cell and Developmental Biology, 2019
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by BCR-ABL1, an oncogenic fusion gene arising from the Philadelphia chromosome. The development of tyrosine kinase inhibitors (TKIs) to overcome the constitutive tyrosine kinase activity of the BCR-ABL protein has dramatically improved disease management and patient ...
Bugler, Jane, Kinstrie, Ross, Scott, Mary T., Vetrie, David   +3 more
openaire   +4 more sources

Epigenetic Metalloenzymes

Current Medicinal Chemistry, 2019
Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe, Linot, Camille, Cartron, Pierre-François, Tomaselli, Daniela, Mai, Antonello, Bertrand, Philippe   +5 more
openaire   +5 more sources

Environmentally Induced Epigenetic Plasticity in Development: Epigenetic Toxicity and Epigenetic Adaptation [PDF]

Current Epidemiology Reports, 2018
Epigenetic processes represent important mechanisms underlying developmental plasticity in response to environmental exposures. The current review discusses three classes of environmentally-induced epigenetic changes reflecting two aspects of that plasticity, toxicity effects as well as adaptation in the process of development.Due to innate resilience,
Fu-Ying, Tian, Carmen J, Marsit
openaire   +2 more sources

Small RNAs in epigenetic inheritance: from mechanisms to trait transmission

, 2021
International audienceInherited information is transmitted to progeny primarily by the genome through the gametes. However, in recent years, epigenetic inheritance has been demonstrated in several organisms, including animals.
Germano Cecere, Cecere, Germano
core   +1 more source

Epigenetics and Psychiatry [PDF]

Neurotherapeutics, 2013
Psychiatric disorders including major depressive disorder, drug addiction, and schizophrenia are debilitating illnesses with a multitude of complex symptoms underlying each of these disorders. In recent years, it has become appreciated that the onset and development of these disorders goes beyond the one gene-one disease approach.
Melissa, Mahgoub, Lisa M, Monteggia
openaire   +2 more sources

The effects of green tea and curcumin on COMT and MAO pathways in nutrigenetics-based epigenetic approaches: Clinical benefits and the balanced management of psycho-oncological risks

Euchembioj Reviews
The worldwide prevalence of all cancer types continues to rise. In this context, the psychological burden of cancer—particularly anxiety and depression—has emerged as a critical yet frequently overlooked component of comprehensive oncological care.
Gulsen Meral, Elif Sibel Aslan, Neval Burkay, Merve Ozkaya, Esma Gokcen Alper Acar   +4 more
doaj   +1 more source