Results 31 to 40 of about 803,735 (311)

Malaria Epigenetics [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Organisms with identical genome sequences can show substantial differences in their phenotypes owing to epigenetic changes that result in different use of their genes. Epigenetic regulation of gene expression plays a key role in the control of several fundamental processes in the biology of malaria parasites, including antigenic variation and sexual ...
Cortés, Alfred, Deitsch, Kirk W.
openaire   +3 more sources

The effects of green tea and curcumin on COMT and MAO pathways in nutrigenetics-based epigenetic approaches: Clinical benefits and the balanced management of psycho-oncological risks

Euchembioj Reviews
The worldwide prevalence of all cancer types continues to rise. In this context, the psychological burden of cancer—particularly anxiety and depression—has emerged as a critical yet frequently overlooked component of comprehensive oncological care.
Gulsen Meral, Elif Sibel Aslan, Neval Burkay, Merve Ozkaya, Esma Gokcen Alper Acar   +4 more
doaj   +1 more source

Bifurcation in epigenetics: implications in development, proliferation and diseases

, 2014
Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of biochemical marks on ...
Jost, Daniel
core   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: Genomics mark epigenetic dysregulation as a primary therapeutic target [PDF]

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there is still no effective B therapy.
Abate F., Agostinelli C., Amente S., Berti E., Bertolini F., Brundu F., Cerroni L., Dellino G. I., Etebari M., Facchetti F., Falini B., Fuligni F., Indio V., Laginestra M. A., Melle F., Motta G., Orecchioni S., Paulli M., Piccioni R., Pileri A., Pileri S. A., Pimpinelli N., Rabadan R., Rossi M., Sabattini E., Sapienza M. R., Tabanelli V., Talarico G., Tarantino G., Tripodo C., Truni M.   +30 more
core   +2 more sources

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source

HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception

Scientific Reports, 2023
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of specificity in transmitting signals and cargo to coordinate local and distant cellular functions.
Christopher P. Morgan, Victoria E. Meadows, Ruth Marx-Rattner, Yasmine M. Cisse, Tracy L. Bale   +4 more
doaj   +1 more source

The importance of detailed epigenomic profiling of different cell types within organs. [PDF]

, 2016
The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea, Laird-Offringa, Ite A, Marconett, Crystal N, Stueve, Theresa Ryan, Zhou, Beiyun   +4 more
core   +1 more source

Epigenetic Mechanisms [PDF]

, 2011
The incidence of diabetes and related complications like nephropathy is growing rapidly and has become a major health care issue. Changes in the environment and nutritional habits have been implicated as major players. Furthermore, it is becoming increasingly clear that epigenetic factors may modulate the connections between genes and the environment ...
Louisa M, Villeneuve, Rama, Natarajan
openaire   +2 more sources

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

Nature Communications, 2016
Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is ...
David Cano-Rodriguez, Rutger A F. Gjaltema, Laura J Jilderda, Pytrick Jellema, Jelleke Dokter-Fokkens, Marcel H J. Ruiters, Marianne G Rots   +6 more
doaj   +1 more source