Results 11 to 20 of about 412,056 (218)
Current Genomics, 2015 The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic patterns during aging) is the gradual decrease of global DNA methylation. Aging cells, different tissue types, as well as a variety of human diseases possess their own distinct DNA methylation profiles, although the functional impact of these is not always clear.
Sierra, Marta I. +2 more
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Computational epigenetics [PDF]
Bioinformatics, 2007 Abstract Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression.
Christoph Bock, Thomas Lengauer
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Epigenetics and depression [PDF]
Dialogues in Clinical Neuroscience, 2019 The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in depression risk following exposure to adverse life events and provide a mechanistic framework within which genetic and environmental factors can be integrated.
Penner-Goeke, Signe +1 more
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American Journal of Lifestyle Medicine, 2018 The field of Epigenetics represents the science which helps us understand the influence life has on genetic function. Research has shown that what we do, what we are exposed to, and the internal and external environments have significant influence on the output of our genes. In this article, the reader will understand how alterations in the DNA explain
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Epigenetics and Lifestyle [PDF]
Epigenomics, 2011 The concept of 'lifestyle' includes different factors such as nutrition, behavior, stress, physical activity, working habits, smoking and alcohol consumption. Increasing evidence shows that environmental and lifestyle factors may influence epigenetic mechanisms, such as DNA methylation, histone acetylation and miRNA expression.
J. A. Alegría Torres +2 more
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Critical Care Medicine, 2020 Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Binnie, Alexandra +5 more
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The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective [PDF]
Frontiers in Genetics, 2017 A single word, Epigenetics, underlies one exciting subject in today's Science, with different sides and with interactions with philosophy. The apparent trivial description includes everything in between genotype and phenotype that occurs for a given unique DNA sequence/genome.
Gemma Navarro +5 more
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Epigenetic Regulation and Measurement of Epigenetic Changes [PDF]
Biological Research For Nursing, 2012 Epigenetic mechanisms provide an adaptive layer of control in the regulation of gene expression that enables an organism to adjust to a changing environment. Epigenetic regulation increases the functional complexity of deoxyribonucleic acid (DNA) by altering chromatin structure, nuclear organization, and transcript stability.
Stephens, Kimberly E +4 more
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Epigenetics and Evolution [PDF]
Integrative and Comparative Biology, 2014 Epigenetic mechanisms traditionally have been studied in the domains of development and disease, but they may also play important roles in ecological and evolutionary processes. In this article, we revisit historical as well as recent studies that indicate significant impacts of epigenetic processes on evolution.
I, Mendizabal +3 more
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Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
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