Results 11 to 20 of about 803,735 (311)
Computational epigenetics [PDF]
Bioinformatics, 2007 Abstract Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression.
Bock, C., Lengauer, T.
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Translational Research, 2015 Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes.
Nian, Liu, Tao, Pan
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American Journal of Lifestyle Medicine, 2018 The field of Epigenetics represents the science which helps us understand the influence life has on genetic function. Research has shown that what we do, what we are exposed to, and the internal and external environments have significant influence on the output of our genes.
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Epigenetics: What it is about? [PDF]
, 2014 Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in
Ogryzko, Vasily, Saade, Evelyne
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chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]
, 2013 Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Azorin, Fernando +3 more
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Environmental epigenetics [PDF]
Heredity, 2010 Epigenetics investigates heritable changes in gene expression that occur without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone modifications, can change genome function under exogenous influence. We review current evidence indicating that epigenetic alterations mediate effects caused by exposure to ...
V. Bollati, A. Baccarelli
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Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]
, 2015 In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia +2 more
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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
, 2015 Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie +17 more
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Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty
Scientific Reports, 2023 The genetic material encoded on X and Y chromosomes provides the foundation by which biological sex differences are established. Epigenetic regulators expressed on these sex chromosomes, including Kdm6a (Utx), Kdm5c, and Ddx3x have far-reaching impacts ...
Kylie D. Rock +6 more
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Women's perception, attitudes, and intended behavior towards predictive epigenetic risk testing for female cancers in 5 European countries: A cross-sectional online survey [PDF]
, 2019 BACKGROUND: Epigenetic markers might be used for risk-stratifying cancer screening and prevention programs in the future. Although the clinical utility of consequent epigenetic tests for risk stratification is yet to be proven, successful adoption into ...
Pashayan, N. +3 more
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