Results 21 to 30 of about 37,500 (218)
Non-Coding RNA, 2022 Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery.
Silvia Di Agostino +3 more
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Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML [PDF]
Frontiers in Cell and Developmental Biology, 2019 Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by BCR-ABL1, an oncogenic fusion gene arising from the Philadelphia chromosome. The development of tyrosine kinase inhibitors (TKIs) to overcome the constitutive tyrosine kinase activity of the BCR-ABL protein has dramatically improved disease management and patient ...
Bugler, Jane +3 more
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Environmentally Induced Epigenetic Plasticity in Development: Epigenetic Toxicity and Epigenetic Adaptation [PDF]
Current Epidemiology Reports, 2018 Epigenetic processes represent important mechanisms underlying developmental plasticity in response to environmental exposures. The current review discusses three classes of environmentally-induced epigenetic changes reflecting two aspects of that plasticity, toxicity effects as well as adaptation in the process of development.Due to innate resilience,
Fu-Ying, Tian, Carmen J, Marsit
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Euchembioj ReviewsThe worldwide prevalence of all cancer types continues to rise. In this context, the psychological burden of cancer—particularly anxiety and depression—has emerged as a critical yet frequently overlooked component of comprehensive oncological care.
Gulsen Meral +4 more
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Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
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Epigenetics and Evolution [PDF]
Integrative and Comparative Biology, 2014 Epigenetic mechanisms traditionally have been studied in the domains of development and disease, but they may also play important roles in ecological and evolutionary processes. In this article, we revisit historical as well as recent studies that indicate significant impacts of epigenetic processes on evolution.
I, Mendizabal +3 more
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Cells, 2020 Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov +7 more
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Scientific Reports, 2023 Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of specificity in transmitting signals and cargo to coordinate local and distant cellular functions.
Christopher P. Morgan +4 more
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Molecules, 2021 Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked to the development of acute leukemias characterized by the MLL (mixed-lineage leukemia ...
Corentin Bon +12 more
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Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
Nature Communications, 2016 Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is ...
David Cano-Rodriguez +6 more
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