Results 201 to 210 of about 865,085 (290)

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

Abnormal epigenetic aging of epigenetic outliers in normal colon mucosa from colorectal cancer patients. [PDF]

Sci Rep
Schultz BM, Ayeotan O, Rana JN, Litwin S, Basickes S, Sapienza C, Ghosh J.   +6 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

DNA Methylation and Its Role in Personalized Nutrition: Mechanisms, Clinical Insights, and Future Perspectives. [PDF]

Int J Mol Sci
Hussain SA, Sarker MI, Liu Y, Jin TZ.
europepmc   +1 more source

Overcoming off-target changes in gene expression by targeting epigenetic enzyme inhibitors to oncogenes using LNA-drug bioconjugates

, 2019
L. Ryan
openalex   +1 more source

Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity [PDF]

, 2006
Joshua P. Cantor, Dimitrios Iliopoulos, Atul Rao, Teresa Druck, Shuho Semba, Shuang‐Yin Han, Kelly A. McCorkell, Thiru V. Lakshman, Joshua E. Collins, Phyllis Wachsberger, Joseph S. Friedberg, Kay Huebner   +11 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications. [PDF]

Signal Transduct Target Ther
Wang X, Luo X, Xiao R, Liu X, Zhou F, Jiang D, Bai J, Cui M, You L, Zhao Y.   +9 more
europepmc   +1 more source

Epigenetic Mechanisms in Lung Cancer

, 2018
Christopher L. Seiler
openalex   +1 more source

The lemon genome and DNA methylome unveil epigenetic regulation of citric acid biosynthesis during fruit development [PDF]

Hang Yu, Chao Zhang, Chuang Lu, Yana Wang, Congcong Ge, Gui‐Xiang Huang, Haifeng Wang   +6 more
openalex   +1 more source