Results 21 to 30 of about 865,085 (290)

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

Stress related epigenetic changes may explain opportunistic success in biological invasions in Antipode mussels [PDF]

, 2018
Different environmental factors could induce epigenetic changes, which are likely involved in the biological invasion process. Some of these factors are driven by humans as, for example, the pollution and deliberate or accidental introductions and others
A Ardura, A Ardura, A Brenkert, A Pecinka, A Pérez-Figueroa, A Salmon, A Zaiko, A Zemach, AB Nicotra, AG Marsh, AK Sakai, AL Liebl, AR Linde, B Bec, B Liu, BM Turner, BR Wilson, CE Braby, CE Lee, CL Richards, DH Lim, DJ Madariaga, DL Strayer, DM Updegraff, E Briski, E Malone, F Devloo-Delva, F Valladares, FJ Santaclara, FT Chan, G Riviere, I Pejovic, J Atalah, J Fulneček, JA Rusiecki, JC Rice, JH McDonald, JM Jones, K Gérard, KJF Verhoeven, KV Kardong, L Alessa, L Excoffier, L Manti, L Miralles, M Barbieri, MA Khadim, MB Vandegehuchte, MJ Lexer, MR Gavery, MR Gavery, O Bossdorf, O Broennimann, P Colosimo, P García-Fernández, P Moran, PA Gardner, PA Jones, R Alquezar, R Karan, R Peakall, R Peakall, R Tingley, RA Zerebecki, S Gofas, S Gollasch, S Pascual, SCH Barrett, SJ Bownes, T Kohama, TJ Hilbish, V Chinnusamy, V Suarez-Ulloa, Y Sun, Ø Hammer   +74 more
core   +2 more sources

Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation

Cells, 2020
Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov, Elena S. Klushevskaya, Daria M. Fedoseeva, Ildar R. Alembekov, Galina I. Kravatskaya, Vladimir R. Chechetkin, Yuri V. Kravatsky, Olga V. Kretova   +7 more
doaj   +1 more source

HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception

Scientific Reports, 2023
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of specificity in transmitting signals and cargo to coordinate local and distant cellular functions.
Christopher P. Morgan, Victoria E. Meadows, Ruth Marx-Rattner, Yasmine M. Cisse, Tracy L. Bale   +4 more
doaj   +1 more source

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

Nature Communications, 2016
Epigenome editing by zinc finger (ZF) and CRISPR-dCas9 technologies can induce or repress gene expression. Here, the authors show that histone methyltransferase PRDM9 fused to either dCas9 or ZF proteins can sustain gene re-expression, and H3K79me is ...
David Cano-Rodriguez, Rutger A F. Gjaltema, Laura J Jilderda, Pytrick Jellema, Jelleke Dokter-Fokkens, Marcel H J. Ruiters, Marianne G Rots   +6 more
doaj   +1 more source

Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein

Molecules, 2021
Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked to the development of acute leukemias characterized by the MLL (mixed-lineage leukemia ...
Corentin Bon, Yang Si, Melanie Pernak, Magdalena Barbachowska, Eva Levi-Acobas, Veronique Cadet Daniel, Corinne Jallet, Dusan Ruzic, Nemanja Djokovic, Teodora Djikić, Katarina Nikolic, Ludovic Halby, Paola B. Arimondo   +12 more
doaj   +1 more source

The importance of detailed epigenomic profiling of different cell types within organs. [PDF]

, 2016
The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea, Laird-Offringa, Ite A, Marconett, Crystal N, Stueve, Theresa Ryan, Zhou, Beiyun   +4 more
core   +1 more source

Bifurcation in epigenetics: implications in development, proliferation and diseases

, 2014
Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of biochemical marks on ...
Jost, Daniel
core   +1 more source

Optimized Bacteria are Environmental Prediction Engines [PDF]

, 2018
Experimentalists have observed phenotypic variability in isogenic bacteria populations. We explore the hypothesis that in fluctuating environments this variability is tuned to maximize a bacterium's expected log growth rate, potentially aided by ...
Crutchfield, James P., Marzen, Sarah E.
core   +4 more sources

Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]

, 2017
Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio, Bianchi, Marzia, Moresi, Viviana, Renzini, Alessandra   +3 more
core   +1 more source