Results 81 to 90 of about 625,174 (305)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

Advanced Science
Intestinal epithelium is derived from Lgr5+ intestinal stem cells (ISCs) located at the crypt base. However, how small nucleolar RNAs (snoRNAs) regulate ISC stemness remains elusive. Here, a conserved snoRNA, Snord15b, that is highly expressed in ISCs is
Yuwei Xu, Peikang Zhang, Zhen Xiong, Yufei Lan, Hui Guo, Runyuan Wu, Cunzhen Li, Hongzhe Fan, Ying Du, Xiaoxiao Zhu, Dongdong Fan, Zhonglong Wang, Yong Tian, Zusen Fan   +13 more
doaj   +1 more source

Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma

Journal of Experimental & Clinical Cancer Research, 2019
Background Over the past decade, newly designed cancer therapies have not significantly improved the survival of patients diagnosed with Malignant Pleural Mesothelioma (MPM).
Claudio Pulito, Etleva Korita, Andrea Sacconi, Mariacristina Valerio, Luca Casadei, Federica Lo Sardo, Federica Mori, Maria Ferraiuolo, Giuseppe Grasso, Anna Maidecchi, Jacopo Lucci, Marius Sudol, Paola Muti, Giovanni Blandino, Sabrina Strano   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA

Nature Communications
The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating ...
Jing Yang, Jiachen Bu, Bowen Liu, Yusheng Liu, Zhuqiang Zhang, Ziyi Li, Falong Lu, Bing Zhu, Yingfeng Li   +8 more
doaj   +1 more source

ZMIZ2 promotes the development of triple-receptor negative breast cancer

Cancer Cell International, 2022
Background Triple-receptor negative breast cancer (TNBC) is an aggressive breast tumor subtype that generally has a poor prognosis. This study aimed to investigate the role and regulatory mechanisms of Zinc finger MIZ-type containing 2 (ZMIZ2) in ...
Xiaopan Zou, Yan Liu, Jun Di, Wei Wei, Nobumoto Watanabe, Jiang Li, Xiaomeng Li   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation of hallmark epigenetic changes in a cancer stem cell model [PDF]

, 2010
Epigenetic control of gene expression is vital for normal development and differentiation of cells, and is also important in the development of disease.
Wild, L.
core  

Epigenetic reprogramming: Prdm14 hits the accelerator [PDF]

, 2012
The EMBO Journal (2012) 31, 2247 - 2248 doi:10.1038/emboj.2012.117 Published online: 20 April 2012 There is an Article (May 2012) associated with this Have you seen?. Epigenetic reprogramming: Prdm14 hits the accelerator Niels Geijsen1 Hubrecht Institute
Tissue Repair, Geneeskunde van gezelschapsdieren, Geijsen, N.   +2 more
core   +1 more source

Environmental epigenetics [PDF]

Heredity, 2010
Epigenetics investigates heritable changes in gene expression that occur without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone modifications, can change genome function under exogenous influence. We review current evidence indicating that epigenetic alterations mediate effects caused by exposure to ...
V. Bollati, A. Baccarelli
openaire   +2 more sources