Results 91 to 100 of about 625,174 (305)

ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes

Nature Communications
DNA G-quadruplexes (G4s), formed by guanine-rich sequences in mammalian genomes, are non-canonical structures implicated in gene regulation. However, their strand-specific genomic distribution and mechanistic roles in transcription remain poorly ...
Sheng Li, Ruoyan Wang, Jinyue Zhang, Changchang Cao, Jiangshan Bai, Zhaokui Cai, Rong Ye, Juan Chen, Wanglong Liu, Chen Lu, Ruitian Li, Yuanchao Xue   +11 more
doaj   +1 more source

Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus

Epigenetics & Chromatin, 2018
Background Contact domains of chromatin serve as a fundamental unit to regulate action of enhancers for target genes. Looping between a pair of CCCTC-binding factor (CTCF)-binding sites in convergent orientations underlies the formation of contact ...
Taro Tsujimura, Osamu Takase, Masahiro Yoshikawa, Etsuko Sano, Matsuhiko Hayashi, Tsuyoshi Takato, Atsushi Toyoda, Hideyuki Okano, Keiichi Hishikawa   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Evolution and conservation of polycomb repressive complex 1 core components and putative associated factors in the green lineage

BMC Genomics, 2019
Background Polycomb group (PcG) proteins play important roles in animal and plant development and stress response. Polycomb repressive complex 1 (PRC1) and PRC2 are the key epigenetic regulators of gene expression, and are involved in almost all ...
Yong Huang, Ling Jiang, Bo-Yu Liu, Cheng-Fang Tan, Dong-Hong Chen, Wen-Hui Shen, Ying Ruan   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Moore, SE, Dominguez-Salas, P, Prentice, AM, Hennig, BJ, Cox, SE   +4 more
core   +3 more sources

Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock

Ecology and Evolution
Knowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff, Milda Milčiūtė, Juozas Gordevičius, Robert Brooke, Todd C. Atwood   +4 more
doaj   +1 more source

IPA Analysis of Cervicovaginal Fluid from Precancerous Women Points to the Presence of Biomarkers for the Precancerous State of Cervical Carcinoma

Proteomes, 2014
Despite large gaps in our knowledge on the intracellular mechanism leading to cervical cancer, the pathways induced by oncogenic high-risk Human Papilloma Virus (HPV) and those finally causing cervical cancer are increasingly being unraveled.
Xaveer Van Ostade, Martin Dom, Geert Van Raemdonck   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]

, 2015
BACKGROUND: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Deary, Ian J., Pattie, Alison, Horvath, Steve, Wray, Naomi R., Harris, Sarah E., Starr, John M., Marioni, Riccardo E, McRae, Allan F, Starr, John M, Murphy, Lee, Ritchie, Stuart J., Muniz-Terrera, Graciela, McRae, Allan F., Ritchie, Stuart J, Marioni, Riccardo E., Taylor, Adele, Deary, Ian J, Visscher, Peter M, Corley, Janie, Murphy, Lee; id_orcid, Redmond, Paul, Wray, Naomi R, Visscher, Peter M., Gibson, Jude, Cox, Simon R, Shah, Sonia, Cox, Simon R., Harris, Sarah E   +27 more
core   +1 more source