Results 91 to 100 of about 803,735 (311)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
ILAR Journal, 2012 Within the last two decades, significant progress has been made in understanding the importance of epigenetic mechanisms in the regulation of gene expression as a consequence of gene-environment interactions. Nutrition, among many other environmental factors, is a key player that can induce epigenetic changes not only in the directly exposed organisms ...
openaire +2 more sources
BMC Genomics, 2019 Background Polycomb group (PcG) proteins play important roles in animal and plant development and stress response. Polycomb repressive complex 1 (PRC1) and PRC2 are the key epigenetic regulators of gene expression, and are involved in almost all ...
Yong Huang +6 more
doaj +1 more source
Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
doaj +1 more source
Introduction: The Third International Conference on Epigenetic Robotics [PDF]
, 2003 This paper summarizes the paper and poster contributions to the Third International Workshop on Epigenetic Robotics. The focus of this workshop is on the cross-disciplinary interaction of developmental psychology and robotics. Namely, the general goal in
Berthouze, Luc, Prince, Christopher G.
core
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
, 2010 Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J +17 more
core +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Current Opinion in Systems Biology, 2017 The field of epigenetics is maturing, with increased interest in understanding the normal regulation of the genome and the possibility that it becomes reprogrammed aberrantly as part of the cause of disease phenotypes. Applying the current technologies and insights to the study of human populations is potentially a way of understanding mechanisms and ...
openaire +2 more sources
ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes
Nature CommunicationsDNA G-quadruplexes (G4s), formed by guanine-rich sequences in mammalian genomes, are non-canonical structures implicated in gene regulation. However, their strand-specific genomic distribution and mechanistic roles in transcription remain poorly ...
Sheng Li +11 more
doaj +1 more source
Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
Journal of Experimental & Clinical Cancer Research, 2019 Background Over the past decade, newly designed cancer therapies have not significantly improved the survival of patients diagnosed with Malignant Pleural Mesothelioma (MPM).
Claudio Pulito +14 more
doaj +1 more source