Results 131 to 140 of about 24,360 (295)

A 2-dimensional Geometry for Biological Time [PDF]

, 2011
This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as ...
Bailly, Bailly, Bailly, Bailly, Botzung, Bourgine, Chaline, Cranford, Fabrizio, Feynman, Francis Bailly, Giuseppe Longo, Goldberger, Hellbrugge, Le Méhauté, Le Van Quyen, Lindstedt, Mael Montevil, Massin, Mortola, Nottale, Savage, Schmidt-Nielsen, Szpunar, Van Gelder, Varela, West, West, West, Winfree   +29 more
core   +4 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms

Clinical Epigenetics
Background Epigenetic clocks assess DNA aging based on DNA methylation. We aimed to study the utility of methylation clocks in understanding the distinct characteristics of sporadic and hereditary neuroendocrine neoplasms (NEN).
Shiri Weinstein, Reut Halperin, Amit Tirosh   +2 more
doaj   +1 more source

Fetal ultrasound measurements and associations with postnatal outcomes in infancy and childhood : a systematic review of an emerging literature [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer ...
Alkandari, Farah, Aucott, Lorna, Devereux, Graham, Ellahi, Awaiss, Turner, Steve   +4 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. [PDF]

, 2016
Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal evolutionary processes.
Berman, Benjamin P, Cai, Yan, Chang, Chen, Dinh, Huy Q, Hao, Jia-Jie, Jiang, Yan-Yi, Jiang, Ye, Koeffler, H Phillip, Lin, De-Chen, Lu, Chen-Chen, Mayakonda, Anand, Shi, Zhi-Zhou, Wang, Jin-Wu, Wang, Ming-Rong, Wei, Wen-Qiang, Xu, Xin, Zhan, Qi-Min, Zhang, Yu   +17 more
core  

Influence of pre-reproductive maternal enrichment on coping response to stress and expression of c-Fos and glucocorticoid receptors in adolescent offspring [PDF]

, 2017
Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function.
Begega, Azucena, Berretta, Erica, Caporali, Paola, Cutuli, Debora, DE BARTOLO, Paola, Foti, FRANCESCA IRENE, Gelfo, Francesca, Laricchiuta, Daniela, Pasqualini, Greta, Pesoli, Matteo, Petrosini, Laura, Sampedro Piquero, Patricia   +11 more
core   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Human in vitro models for understanding mechanisms of autism spectrum disorder. [PDF]

, 2020
Early brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental ...
Geschwind, Daniel H, Gordon, Aaron
core