Results 161 to 170 of about 431,319 (321)

The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes

Neurobiology of Disease, 2021
Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date.
Francine Grodstein, Bernardo Lemos, Lei Yu, Hans-Ulrich Klein, Artemis Iatrou, Aron S. Buchman, Gemma L. Shireby, Jonathan Mill, Julie A. Schneider, Philip L. De Jager, David A. Bennett   +10 more
doaj  

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Epigenetic clock: a promising mirror of ageing [PDF]

The Lancet Healthy Longevity, 2021
Zuyun Liu, Zuyun Liu, Yimin Zhu
openaire   +4 more sources

Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer

Cancer Biology & Medicine
Objective: Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive.
Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang   +9 more
doaj   +1 more source

RECENT RESULTS ON THE EPIGENETIC CLOCK [PDF]

, 2015

openalex   +1 more source

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina [PDF]

, 2021
Zhong Chen, Seta Stanbouly, Nina C. Nishiyama, Xin Chen, Michael D. Delp, Hongyu Qiu, Xiao Wen Mao, Charles Wang   +7 more
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

BMC Medicine
Background Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration.
Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg   +10 more
doaj   +1 more source

Age-related changes in blood-brain barrier integrity in C57BL/6J mice [PDF]

, 2013
The blood-brain barrier (BBB) is formed by the endothelial cells of the brain microvasculature, which control the molecular traffic between the blood and brain to maintain the neural ...
Romero, I. A., Saffrey, M. J., Wang, C.
core  

Epigenetic clock analyses of cellular senescence and ageing [PDF]

, 2016
Donna Lowe, Steve Horvath, Kenneth Raj
openalex   +1 more source