Results 191 to 200 of about 431,319 (321)

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Exposure to Violence Accelerates Epigenetic Aging in Children

Scientific Reports, 2017
Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”.
Tanja Jovanovic, L. Alexander Vance, Dorthie Cross, Anna K. Knight, Varun Kilaru, Vasiliki Michopoulos, Torsten Klengel, Alicia K. Smith   +7 more
doaj   +1 more source

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts [PDF]

, 2019
Juulia Jylhävä, Jacob Hjelmborg, Mette Soerensen, Elizabeth Muñoz, Qihua Tan, Ralf Kuja‐Halkola, Jonas Mengel‐From, Kaare Christensen, Lene Christiansen, Sara Hägg, Nancy L. Pedersen, Chandra A. Reynolds   +11 more
openalex   +1 more source

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity [PDF]

, 2020
Kyle M. Schachtschneider, Lawrence B. Schook, Jennifer J. Meudt, Dhanansayan Shanmuganayagam, Joseph A. Zoller, Amin Haghani, Caesar Z. Li, Joshua Zhang, Andrew X. Yang, Ken Raj, Steve Horvath   +10 more
openalex   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Molecular Markers of Aging and Exercise Capacity in COPD: The Epigenetic Clock Versus Telomeres [PDF]

, 2020
Emily S. Wan, Rebekah L. Goldstein, Eric Garshick, Dawn L. DeMeo, Marilyn L. Moy   +4 more
openalex   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

EPIGENETIC CLOCKS OF COMPUTED TOMOGRAPHY MEASURES OF FATTY ORGANS [PDF]

, 2019
Ake T Lu, Steve Horvath
openalex   +1 more source