Results 111 to 120 of about 2,250,202 (262)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Systems level analysis of transgenerational spermatogenic inheritance predicts biomarkers and underlying pathways [PDF]

, 2009
Transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics has recently been discovered using a Drosophila systems model.
Abhay Sharma
core  

Dictating genomic destiny: Epigenetic regulation of pancreatic neuroendocrine tumours

, 2018
Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly well-defined genomic basis. Despite this, much of what drives this disease is still unknown and epigenetic influences represent the next tier of gene, and hence ...
Kurzawinski, Tom, Jamal, Karim, Karim Jamal, Justin S. Gundara, Tom Kurzawinski, Gundara, Justin S   +5 more
core   +1 more source

PB2480: LENTIVIRAL LABELING OF STROMAL LAYER OF LONG-TERM BONE MARROW CULTURE DEMONSTRATED INEFFICIENCY FOR MESENCHYMAL STEM CELLS AND CONTRIBUTION OF NON-STEM CELLS TO HEMATOPOIETIC ECTOPIC FOCUS IN MICE

HemaSphere, 2023
Dmitriy Karpenko, Aleksei Bigildeev
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]

, 2009
We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Rodrick Wallace, Wallace, Rodrick
core  

Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes

, 2004
Post-translational modifications of histone amino termini are thought to convey epigenetic information that extends the coding potential of DNA. In particular, histone lysine methylation has been implicated in conveying transcriptional memory and ...
Caparros, M.L., Arney, K., Fisher, Amanda G., Merkenschlager, Matthias, Arney, Katharine, Williams, R., Baxter, Jonathan, John, Rosalind Margaret, Caparros, Marie-Laure, Sauer, S., Merkenschlager, M., Sauer, Stephan, Jenuwein, Thomas, Fisher, A.G., Jenuwein, T, Otte, A.P., Baxter, J, Otte, Arie, Peters, Antoine, Williams, Ruth, Peters, E.A.J.F., John, R.   +21 more
core   +1 more source

Chromatin state analysis of the barley epigenome reveals a higher-order structure defined by H3K27me1 and H3K27me3 abundance [PDF]

, 2015
This work was supported by grant BBSRC BB/I1022899/1 ‘The diversity and evolution of the gene component of the barley pericentromeric heterochromatin’.Combinations of histones carrying different covalent modifications are a major component of epigenetic ...
Dhillon, Taniya, Milne, Iain, Katie Baker, Baker, Katie, Colas, Isabelle, Taniya Dhillon, Micha Bayer, Bayer, Micha, Milne, Linda, Linda Milne, Flavell, Andrew J., Iain Milne, Andrew J. Flavell, Cook, Nicola, Nicola Cook, Isabelle Colas   +15 more
core   +1 more source

HBV-associated hepatocellular carcinomas inhibit antitumor CD8+ T cell via the long noncoding RNA HDAC2-AS2

Nature Communications
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Extracellular vesicles (EV) are critical mediators of intercellular communication within the tumor microenvironment, and cancer-cell-secreted EVs often facilitate cancer ...
Yanan Gao, Zhenxing Zhang, Xuetao Huang, Maojun You, Chengzhi Du, Nan Li, Yajing Hao, Kang Wang, Xiang Ding, Fuquan Yang, Shu-qun Cheng, Jianjun Luo, Runsheng Chen, Pengyuan Yang   +13 more
doaj   +1 more source

Protocol for profiling virus-to-host RNA-RNA interactions in infected cells by RIC-seq

STAR Protocols
Summary: Virus-to-host RNA-RNA interactions directly regulate host mRNA stability and viral replication. However, globally profiling virus-to-host in situ RNA-RNA interactions remains challenging.
Zhaokui Cai, Hailian Zhao, Yuanchao Xue
doaj   +1 more source