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Epigenetic regulation of mechanotransduction

Nature Biomedical Engineering, 2021
The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
Ryan Stowers, Ovijit Chaudhuri
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Epigenetic regulation in obesity

International Journal of Obesity, 2011
The availability to the DNA strand and the activity of the transcription machinery is crucial for the cell to use the information in the DNA. The epigenetic mechanisms DNA methylation, modification of histone tails, other chromatin-modifying processes and interference by small RNAs regulate the cell-type-specific DNA expression. Epigenetic marks can be
C, Lavebratt, M, Almgren, T J, Ekström
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MicroRNAs: Milk's epigenetic regulators

Best Practice & Research Clinical Endocrinology & Metabolism, 2017
Our perception of milk has changed from a "simple food" to a highly sophisticated maternal-neonatal nutrient and communication system orchestrating early programming of the infant. Milk miRNAs delivered by exosomes and milk fat globules derived from mammary gland epithelial cells play a key role in this process.
Bodo C, Melnik, Gerd, Schmitz
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Epigenetic Regulation

2015
Some of the key epigenetic regulatory mechanisms appeared early during evolution, and the acquisition of novel epigenetic regulators apparently facilitated certain evolutionary transitions. In this short review we focus mainly on the major epigenetic mechanisms that control chromatin structure and accessibility in mammalian cells.
Minárovits János   +3 more
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Epigenetic regulation of melanogenesis

Ageing Research Reviews, 2021
Melanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides.
Shihang Zhou   +12 more
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Epigenetic regulation of adipogenesis

Current Opinion in Clinical Nutrition and Metabolic Care, 2012
Epigenetic regulation plays an essential role in cell differentiation, by allowing the establishment and maintenance of the gene-expression pattern of the mature cell type. Because of its importance in chronic diseases, adipogenesis is one of the best-studied differentiation processes.
Melina M, Musri, Marcelina, Párrizas
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Epigenetic regulation in obesity

Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Research suggests that 65% of variation in obesity is genetic. However, much of the known genetic associations have little known function and their effect size small, thus the gene-environment interaction, including epigenetic influences on gene expression, is suggested to be an important factor in the susceptibilty to obesity. This review will explore
Elaine M, Drummond, Eileen R, Gibney
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Epigenetic Regulation of Glycosylation

2021
Expression of glycosylation-related genes (or glycogenes) is strictly regulated by transcription factors and epigenetic processes, both in normal and in pathological conditions. In fact, glycosylation is an essential mechanism through which proteins and lipids are modified to perform a variety of biological events, to adapt to environment, and to ...
Indellicato R., Trinchera M.
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Epigenetics: Regulation Through Repression

Science, 1999
Epigenetics is the study of heritable changes in gene expression that occur without a change in DNA sequence. Epigenetic phenomena have major economic and medical relevance, and several, such as imprinting and paramutation, violate Mendelian principles.
A P, Wolffe, M A, Matzke
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