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Epigenetic Regulation of Pluripotency
2010Epigenetic regulation refers to the mechanisms that alter gene expression patterns in the absence of changes in the nucleotide sequence of the DNA molecule. The best understood epigenetic marks include posttranslational modifications of the histone tails and DNA methylation. Both play central roles in normal development and in diseases.
Eleni M, Tomazou, Alexander, Meissner
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Epigenetic regulation of flowering
Current Opinion in Plant Biology, 2007The acceleration of flowering by prolonged low temperature treatment (vernalization) has unique properties including the floral transition occurring at a time separate from the vernalization treatment. This implies the vernalization condition is inherited through mitotic divisions, but this vernalized state is not inherited from one generation to the ...
E S, Dennis, W J, Peacock
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Epigenetic Regulation in Drosophila
2006Epigenetic regulation of gene transcription relies on molecular marks like DNA methylation or histone modifications. Here we review recent advances in our understanding of epigenetic regulation in the fruit fly Drosophila melanogaster. In the past, DNA methylation research has primarily utilized mammalian model systems. However, several recent landmark
F, Lyko, C, Beisel, J, Marhold, R, Paro
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Epigenetic Regulation in Psychiatric Disorders
Focus, 2007Many neurological and most psychiatric disorders are not due to mutations in a single gene; rather, they involve molecular disturbances entailing multiple genes and signals that control their expression. Recent research has demonstrated that complex 'epigenetic' mechanisms, which regulate gene activity without altering the DNA code, have long-lasting ...
Nadia, Tsankova +3 more
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Epigenetic Regulation of Autophagy
2019Epigenetics refers to reversible and hereditary changes in gene expression without alterations in DNA sequences, such as DNA methylation, histone modification and chromatin remodelling. It was first proposed by Waddington in the book Introduction to Modern Genetics in 1939.
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Epigenetic Regulation in Cystogenesis
2016Epigenetic regulation refers to heritable changes in gene expression that do not involve any alteration of the DNA sequence. DNA methylation, histone modification, and gene regulation by microRNAs are well-known epigenetic modulations that are closely associated with several cellular processes and diverse disease states, such as cancers, even under ...
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Treg Cells and Epigenetic Regulation
2021The discovery of the epigenetic regulation of Treg cells, a cell population with fundamental immunoregulatory properties, has shed considerable insights into an understanding of the role of these cells in health and disease. Research over the past several years has shown that the interaction of Treg cells with the gut microbiota are critical not only ...
Joseph A, Bellanti, Dongmei, Li
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Epigenetics in Cardiovascular Regulation
2016Epidemiological studies have shown an association between pathologic events occurring during early life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called fetal programming of adult disease hypothesis. In line with this hypothesis, short-term exposure to hypoxia after birth predisposes
Claudio, Sartori +4 more
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Epigenetic regulation of stress
Stress can have powerful and lasting effects on our bodies and behavior, partly because it changes how our genes work. These processes, such as DNA methylation, histones modifications, and non-coding RNAs, help decide when genes are active or inactive in cells experiencing stress. This can lead to lasting changes in how the cells function.Mariam K, Alamoudi +3 more
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Epigenetic regulation of cardiac fibrosis
Cellular Signalling, 2013Cardiac fibrosis is characterized by excessive extracellular matrix accumulation that ultimately destroys tissue architecture and eventually abolishes normal function. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic modifications impact on the development of cardiac ...
Hui, Tao +5 more
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