Results 81 to 90 of about 2,250,202 (262)

SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis

Nature Communications
Whether small nucleolar RNAs (snoRNAs) are involved in the regulation of liver cancer stem cells (CSCs) self-renewal and serve as therapeutic targets remains largely unclear.
Yang Gu, Zhibin Yi, Ziheng Zhou, Jianyi Wang, Shan Li, Pingping Zhu, Nian Liu, Yuwei Xu, Lei He, Yanying Wang, Zusen Fan   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPα blockade efficacy

Nature Communications
Type I interferons have been well recognized for their roles in various types of immune cells during tumor immunotherapy. However, their direct effects on tumor cells are less understood.
Hang Zhou, Wenjun Wang, Hairong Xu, Yong Liang, Jiyu Ding, Mengjie Lv, Boyang Ren, Hua Peng, Yang-Xin Fu, Mingzhao Zhu   +9 more
doaj   +1 more source

A Multi-Model Strategy for Optimizing Hepatitis B Virus preS1 Epitope Recognition by the Antibody HzKR127

Current Issues in Molecular Biology
Functional cure of chronic hepatitis B virus (HBV) infection remains a significant challenge, making viral-entry-blocking antibodies a promising antiviral strategy.
Wenqing Chen, Yuanzhong Tu, Kai Wang, Runze Xie, Pengyuan Yang, Yanan Gao, Wenxiang Huang   +6 more
doaj   +1 more source

Regulation of animal behavior by epigenetic regulators

Frontiers in Bioscience, 2019
Epigenetic regulation in animals induces rapid and long-lasting effects on gene expression in response to environmental changes that frequently affect animal behavior. In the last decade, accumulating studies have revealed how epigenetic regulation affects the behavior of animals, such as learning and memory, mating and courtship, the circadian sleep ...
Kouhei, Shimaji, Saki, Tomida, Masamitsu, Yamaguchi   +2 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Epigenetic regulation of chemokine/chemokine receptor expression

, 2013
Epigenetic regulation of gene expression is an important event for normal cellular homeostasis. Gene expression may be "switched" on or "turned" off via epigenetic means through adjustments in DNA architecture.
Gray , Steven G., Kenneth J. O’Byrne, Anne-Marie Baird, Baird, Anne-Marie, O'Byrne, Kenneth J., Steven G. Gray   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Central nervous system resilience to cyclophosphamide: preserved behavior, astrocytes and LGALS3 expression in immunosuppressed mice

Brain, Behavior, & Immunity - Health
Background: Cyclophosphamide is widely used as an immunosuppressive agent in experimental models. However, its potential effect on central nervous system (CNS) function and behavior may confound studies investigating neuroimmune interactions ...
Rogério Aires, Alex de Camargo Coque, Lucas Maruchi Delapena Silva, Arila Adorno Scorzafava Gonçalves, Liebert Bernardes Carvalho, Rafael Lopes Correia Tagliaferri, Elizabeth Cristina Perez Hurtado, Eduardo Bondan, José Guilherme Xavier, Maria Martha Bernardi, Rodrigo Augusto Foganholi da Silva   +10 more
doaj   +1 more source

RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation

Molecular Systems Biology, 2017
Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. However, it is unknown whether RNAPII poising
Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo   +11 more
doaj   +1 more source