Results 61 to 70 of about 2,250,202 (262)

Epigenetic regulation in fibrosis progress

Pharmacological Research, 2021
Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair response disorder when organs undergo continuous damage, ultimately leading to scar formation and functional failure. Around the world, fibrotic diseases cause high mortality, unfortunately, with limited treatment means in clinical practice.
Taixiong, Xue, Xingyu, Qiu, Hongyao, Liu, Cailing, Gan, Zui, Tan, Yuting, Xie, Yuxi, Wang, Tinghong, Ye   +7 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Transcriptional memory emerges from cooperative histone modifications [PDF]

, 2011
Background Transcriptional regulation in cells makes use of diverse mechanisms to ensure that functional states can be maintained and adapted to variable environments; among them are chromatin-related mechanisms.
Thimo Rohlf, Hans Binder, Lydia Steiner, Sonja Prohaska, Joerg Galle   +4 more
core  

An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. [PDF]

, 2012
17/09/13 meb. Open access version uploaded, Ok to pubEnvironmental factors during early life are critical for the later metabolic health of the individual and of future progeny.
Radford, Elizabeth J., Elvira Isganaitis (171907), Ferguson-Smith, Anne C., Simon Andrews (93500), Elizabeth J Radford, David Sassoon, Michael Molla (171916), Didier, N, McEwen, K, Marika Charalambous, McEwen, Kirsten, Didier Nathalie, Patti, ME, Sassoon, David, Radford Elizabeth J., Elizabeth J. Radford (171901), Schroeder, Joshua, Anne C Ferguson-Smith, Jimenez-Chillaron, J, Charalambous, Marika, Isganaitis, Elvira, Andrews, Simon, Mary-Elizabeth Patti (171938), Andrews Simon, Mary-Elizabeth Patti, Nathalie Didier, Molla, Michael, Ferguson-Smith, AC, Radford, EJ, Marazzi, G, Didier, Nathalie, Marazzi Giovanna, Patti Mary-Elizabeth, Jimenez-Chillaron Josep, McEwen Kirsten, Giovanna Marazzi, Andrews, S, Simon Andrews, Jimenez-Chillaron, Josep, Josep Jimenez-Chillaron, Charalambous, M, Marazzi, Giovanna, Kirsten McEwen, Schroeder, J, Molla Michael, David Sassoon (171934), Joshua Schroeder (171914), Nathalie Didier (171919), Sassoon, D, Anne C. Ferguson-Smith (127005), Charalambous Marika, Patti, Mary-Elizabeth, Molla, M, Kirsten McEwen (171925), Josep Jimenez-Chillaron (171910), Giovanna Marazzi (171930), Schroeder Joshua, Elvira Isganaitis, Joshua Schroeder, Michael Molla, Marika Charalambous (171922), Patti, M-E, Sassoon David, Isganaitis, E, Isganaitis Elvira, Ferguson-Smith Anne C.   +65 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Epigenetic regulation of oxysterol formation [PDF]

Biochimie, 2013
Oxysterols are oxygenated derivatives of cholesterol that may be formed by either enzymatic or non-enzymatic mechanisms. Expression of the genes responsible for oxysterol synthesis (GROS) is known to be restricted across different tissues and cell types.
openaire   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress [PDF]

, 2012
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) and brain-derived ...
Dempster, E., Dempster, Emma, Unternaehrer, Eva, Lieb, Roselind, Meyer, A. H., Unternaehrer, E., Luers, P., Mill, J., Staehli, S., Hellhammer, D. H., Meyer, Andrea H., Lieb, R., Meinlschmidt, G., Staehli, Simon, Mill, John, Hellhammer, Dirk H., Meinlschmidt, Gunther   +16 more
core   +1 more source