Results 91 to 100 of about 495,214 (384)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Molecular epigenetics in the management of ovarian cancer: Are we investigating a rational clinical promise?

Frontiers in Oncology, 2014
Epigenetics is essentially a phenotypical change in gene expression without any alteration of the DNA sequence; the emergence of epigenetics in cancer research and mainstream oncology is fueling new hope.
Ha eNguyen, Tian eGeng, Tian eGeng, Mandi eMurph   +3 more
doaj   +1 more source

Cancer epigenetics [PDF]

Human Molecular Genetics, 2005
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our understanding of chromatin structure, histone modification, transcriptional activity and DNA methylation have resulted in an increasingly integrated view of epigenetics. In response to these insights, epigenetic therapy is expanding to include combinations of histone
openaire   +2 more sources

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. [PDF]

, 2016
BackgroundThe robustness of ChIP-seq datasets is highly dependent upon the antibodies used. Currently, polyclonal antibodies are the standard despite several limitations: They are non-renewable, vary in performance between lots and need to be validated ...
Busby, Michele, Cornett, Evan M, Epstein, Charles B, Farjoun, Yossi, Gienger, Elizabeth, Gladden, Adrianne, Goren, Alon, Li, Catherine, Nusbaum, Chad, Rothbart, Scott B, Xue, Catherine, Yofe, Ido   +11 more
core   +1 more source

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside

Clinical Epigenetics, 2021
Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside.
Federica Sarno, G. Benincasa, M. List, A. Barabasi, J. Baumbach, F. Ciardiello, S. Filetti, Kimberly Glass, J. Loscalzo, C. Marchese, B. Maron, P. Paci, P. Parini, E. Petrillo, E. Silverman, A. Verrienti, L. Altucci, C. Napoli, the International Network Medicine Consortium   +18 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics

Nature Communications
DNA methylation patterns at crucial short sequence features, such as enhancers and promoters, may convey key information about cell lineage and state. The need for high-resolution single-cell DNA methylation profiling has therefore become increasingly ...
Nathan J. Spix, Walid Abi Habib, Zhouwei Zhang, Emily Eugster, Hsiao-yun Milliron, David Sokol, KwangHo Lee, Paula A. Nolte, Jamie L. Endicott, Kelly F. Krzyzanowski, Toshinori Hinoue, Jacob Morrison, Benjamin K. Johnson, Wanding Zhou, Hui Shen, Peter W. Laird   +15 more
doaj   +1 more source

Progress in mitochondrial epigenetics

Biomolecular Concepts, 2013
Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways.
Manev Hari, Dzitoyeva Svetlana
doaj   +1 more source

An Epigenetic Role of Mitochondria in Cancer

Cells, 2022
Mitochondria are not only the main energy supplier but are also the cell metabolic center regulating multiple key metaborates that play pivotal roles in epigenetics regulation.
Yu’e Liu, Chao Chen, Xinye Wang, Yihong Sun, Jin Zhang, Juxiang Chen, Yufeng Shi   +6 more
doaj   +1 more source

Beyond DNA: Epigenetics and Proteomics in Forensic Science [PDF]

, 2016
The use of genetic evidence in criminal cases is well established and has improved the public opinion and credibility of forensic science. However, several shortcomings associated with current genetic profiling techniques exist. Scientific research aimed
Eilerts, Diane F
core   +1 more source