Results 71 to 80 of about 348,521 (309)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2014 DNA tumor viruses including members of the polyomavirus, adenovirus, papillomavirus, and herpes virus families are presently the subject of intense interest with respect to the role that epigenetics plays in control of the virus life cycle and the transformation of a normal cell to a cancer cell.
Barry I, Milavetz, Lata, Balakrishnan
openaire +2 more sources
Nature CommunicationsDNA methylation patterns at crucial short sequence features, such as enhancers and promoters, may convey key information about cell lineage and state. The need for high-resolution single-cell DNA methylation profiling has therefore become increasingly ...
Nathan J. Spix +15 more
doaj +1 more source
Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology
Current Issues in Molecular BiologyTechnological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and ...
Wan Ying Tan +8 more
doaj +1 more source
Clinical Epigenetics, 2012 Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins.
Kubota Takeo +2 more
doaj +1 more source
An operational definition of epigenetics.
Genes & Development, 2009 A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by the Banbury Conference Center and Cold Spring Harbor Laboratory.
S. Berger +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML [PDF]
Frontiers in Cell and Developmental Biology, 2019 Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by BCR-ABL1, an oncogenic fusion gene arising from the Philadelphia chromosome. The development of tyrosine kinase inhibitors (TKIs) to overcome the constitutive tyrosine kinase activity of the BCR-ABL protein has dramatically improved disease management and patient ...
Bugler, Jane +3 more
openaire +4 more sources
Epigenetic profiling to environmental stressors in model and non-model organisms: Ecotoxicology perspective [PDF]
Environmental Health and Toxicology, 2018 Epigenetics, potentially heritable changes in genome function that occur without alterations to DNA sequence, is an important but understudied component of ecotoxicology studies.
Nivedita Chatterjee +2 more
doaj +1 more source
The Contribution of Epigenetics to Cancer Immunotherapy.
Trends in immunology, 2020 Effective anticancer immunotherapy treatments constitute a qualitative leap in cancer management. Nonetheless, not all patients benefit from such therapies because they fail to achieve complete responses, suffer frequent relapses, or develop potentially ...
L. Villanueva +2 more
semanticscholar +1 more source