Results 71 to 80 of about 224,057 (304)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Molecular epigenetics in the management of ovarian cancer: Are we investigating a rational clinical promise?

Frontiers in Oncology, 2014
Epigenetics is essentially a phenotypical change in gene expression without any alteration of the DNA sequence; the emergence of epigenetics in cancer research and mainstream oncology is fueling new hope.
Ha eNguyen, Tian eGeng, Tian eGeng, Mandi eMurph   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics

Nature Communications
DNA methylation patterns at crucial short sequence features, such as enhancers and promoters, may convey key information about cell lineage and state. The need for high-resolution single-cell DNA methylation profiling has therefore become increasingly ...
Nathan J. Spix, Walid Abi Habib, Zhouwei Zhang, Emily Eugster, Hsiao-yun Milliron, David Sokol, KwangHo Lee, Paula A. Nolte, Jamie L. Endicott, Kelly F. Krzyzanowski, Toshinori Hinoue, Jacob Morrison, Benjamin K. Johnson, Wanding Zhou, Hui Shen, Peter W. Laird   +15 more
doaj   +1 more source

Progress in mitochondrial epigenetics

Biomolecular Concepts, 2013
Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways.
Manev Hari, Dzitoyeva Svetlana
doaj   +1 more source

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
A. D. McAinsh, A. Desai, A. F. Straight, A. Losada, A. Musacchio, B. A. Sullivan, B. E. Black, B. G. Mellone, B. R. Brinkley, BA Sullivan, C. E. Sunkel, C. E. Walczak, CJ Lawrence, D. Foltz, D. M. Glover, D. W. Cleveland, D. W. Gerlich, DK Palmer, DR Foltz, E. D. Salmon, ES Alnemri, G. J. Gorbsky, G. J. P. L. Kops, G. Karpen, G. P. Copenhaver, H. F. Willard, H. Maiato, H. Masumoto, I. M. Cheeseman, J Ohzeki, J. G. DeLuca, J. R. Swedlow, K. Bloom, K. C. Scott, K. F. Sullivan, K. H. A. Choo, K. Luger, K. Oegema, K. Yoda, KF Sullivan, L. E. T. Jansen, L. Wordeman, M. A. Lampson, M. Fitzgerald-Hayes, M. Yanagida, MD Blower, P. E. Warburton, P. Heun, P. Meraldi, P. S. Maddox, P. T. Stukenberg, PB Talbert, R. C. Allshire, R. Gassmann, R. J. O’Neill, R. L. Margolis, S Ando, S Henikoff, S Stoler, S. C. Harrison, S. Diekmann, S. Erhardt, S. M. Lens, S. Westermann, SA Ribeiro, T Hori, T Nishino, T. Fukagawa, T. Hirota, T. J. Yen, W. Brown, W. C. Earnshaw, WC Earnshaw   +72 more
core   +9 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Epigenetic profiling to environmental stressors in model and non-model organisms: Ecotoxicology perspective [PDF]

Environmental Health and Toxicology, 2018
Epigenetics, potentially heritable changes in genome function that occur without alterations to DNA sequence, is an important but understudied component of ecotoxicology studies.
Nivedita Chatterjee, Jiwan Gim, Jinhee Choi   +2 more
doaj   +1 more source

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. [PDF]

, 2019
BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Bates, Sofie L, Carter, Sakereh S, Farnham, Peggy J, Fink, Kyle D, Halmai, Julian, Nisson, Karly A, O'Geen, Henriette, Rhie, Suhn K, Segal, David J   +8 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source