Results 71 to 80 of about 153,638 (306)

Epigenetics of infectious diseases

, 2021
Infectious diseases are a leading cause of human morbidity and mortality worldwide, and they are caused by a variety of pathogenic bacteria, viruses, parasites, and fungi.
M.P. Jennings, K.L. Seib, Jennings, MP, Seib, KL   +3 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology

Current Issues in Molecular Biology
Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and ...
Wan Ying Tan, Snigdha Nagabhyrava, Olivia Ang-Olson, Paromita Das, Luisa Ladel, Bethsebie Sailo, Linda He, Anup Sharma, Nita Ahuja   +8 more
doaj   +1 more source

Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

Clinical Epigenetics, 2012
Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins.
Kubota Takeo, Miyake Kunio, Hirasawa Takae   +2 more
doaj   +1 more source

Epigenetics in the public sphere: interdisciplinary perspectives [PDF]

, 2019
International audienceDespite the high public interest in epigenetics, few scholars have empirically investigated the forms, reasons and consequences of the public circulation of epigenetics.
Le Goff, Anne, Louvel, Séverine, Allard, Patrick, Guaspare, Catherine, Dubois, Michel   +4 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Epigenetics-potential for programming fish for aquaculture?

, 2015
Epigenetics-potential for programming fish for ...
H Moghadam (17268493), T Mørkøre (17302090), Nick Robinson (16684536)   +2 more
core   +1 more source

High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics

Nature Communications
DNA methylation patterns at crucial short sequence features, such as enhancers and promoters, may convey key information about cell lineage and state. The need for high-resolution single-cell DNA methylation profiling has therefore become increasingly ...
Nathan J. Spix, Walid Abi Habib, Zhouwei Zhang, Emily Eugster, Hsiao-yun Milliron, David Sokol, KwangHo Lee, Paula A. Nolte, Jamie L. Endicott, Kelly F. Krzyzanowski, Toshinori Hinoue, Jacob Morrison, Benjamin K. Johnson, Wanding Zhou, Hui Shen, Peter W. Laird   +15 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Progress in mitochondrial epigenetics

Biomolecular Concepts, 2013
Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways.
Manev Hari, Dzitoyeva Svetlana
doaj   +1 more source