Results 61 to 70 of about 150,500 (308)
Epigenetics of muscle disorders
, 2016 As heritable information apart from the DNA sequence itself, epigenetics represents a higher level of complexity in the regulation of gene expression and allows for a wide range of outputs.
MORESI, Viviana +7 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Methodological challenges in developmental human behavioral epigenetics: Insights into study design [PDF]
, 2018 Developmental human behavioral epigenetics (DHBE) holds potential for contributing to better understanding of how early life exposures contribute to human developmental trajectories and to inform clinical practice and early interventions.
Livio Provenzi +5 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
Nature Communications, 2019 PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant ...
Gintarė Sendžikaitė +4 more
doaj +1 more source
The Social Brain Meets the Reactive Genome: Neuroscience, Epigenetics and the New Social Biology
Frontiers in Human Neuroscience, 2014 The rise of molecular epigenetics over the last few years promises to bring the discourse about the sociality and susceptibility to environmental influences of the brain to an entirely new level.
Maurizio eMeloni
doaj +1 more source
Biomedicines, 2023 Genetic information is not transmitted solely by DNA but by the epigenetics process. Epigenetics describes molecular missing link pathways that could bridge the gap between the genetic background and environmental risk factors that contribute to the ...
Wiwin Is Effendi, Tatsuya Nagano
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Epigenetics-potential for programming fish for aquaculture?
, 2015 Epigenetics-potential for programming fish for ...
H Moghadam (17268493) +2 more
core +1 more source
Frontiers in Oncology, 2014 Epigenetics is essentially a phenotypical change in gene expression without any alteration of the DNA sequence; the emergence of epigenetics in cancer research and mainstream oncology is fueling new hope.
Ha eNguyen +3 more
doaj +1 more source