Results 91 to 100 of about 153,638 (306)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Barcelona conference on epigenetics and cancer: 50 years of histone acetylation [PDF]

, 2018
The Barcelona Conference on Epigenetics and Cancer (BCEC) was held in Barcelona, Spain, on October 1 and 2 , 2014. The meeting was co-organized by the Cancer Epigenetics and Biology Program (PEBC-IDIBELL) and B·Debate, an initiative of Biocat, with the ...
Simó-Riudalbas, Laia, Ausió, Juan, Pérez Salvia, Montserrat, Esteller, Manel, Esteller, Manel, 1968-   +4 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Epigenetics—Innovations and Misconceptions

Natural Sciences
Epigenetics is a scientific field whose definition has changed over time. Established in the 1940s by C.H. Waddington by synthesis from embryology and genetics, the term “epigenetics” is now mainly used to describe the role of chromatin modifications in ...
Bernhard Horsthemke
doaj   +1 more source

Epigenetics of muscle disorders

, 2016
As heritable information apart from the DNA sequence itself, epigenetics represents a higher level of complexity in the regulation of gene expression and allows for a wide range of outputs.
MORESI, Viviana, V. Moresi, S. Adamo, E. Pigna, MARRONCELLI, NICOLETTA, PIGNA, EVA, ADAMO, Sergio, N. Marroncelli   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Epigenetics and Arterial Hypertension

, 2017
Arterial hypertension; Cardiovascular diseases; Chromatin remodeling; DNA methylation; Epigenetics; Histone acetylation; Histone methylation; Histone modifications; MicroRNAs; Small noncoding ...
O. Olivieri, PIZZOLO, Francesca, OLIVIERI, Oliviero, C.A. Carvajal, F. Pizzolo, C.E. Fardella, FRISO, Simonetta, Carvajal, C. A., Fardella, C. E., S. Friso   +9 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Preface to nutrition and epigenetics

, 2009
The scope of this book is to focus on this novel, fascinating field pertaining to the role of nutritional factors in affecting epigenetic mechanisms therefore highlighting the vast topic that derives from a better understanding of the function of ...
FRISO, Simonetta, Sang Woon Choi
core   +1 more source

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks

Genome Biology
Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers.
Christopher D. Todd, Jannat Ijaz, Fereshteh Torabi, Oleksandr Dovgusha, Stephen Bevan, Olivia Cracknell, Tim Lohoff, Stephen Clark, Ricard Argelaguet, Juliette Pearce, Ioannis Kafetzopoulos, Alice Santambrogio, Jennifer Nichols, Ferdinand von Meyenn, Ufuk Günesdogan, Stefan Schoenfelder, Wolf Reik   +16 more
doaj   +1 more source