Results 101 to 110 of about 495,214 (384)

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]

, 2015
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C, Ashworth, A, Baglietto, L, Chadeau, M, Curry, E, Flanagan, JM, Flower, K, Frasca, G, Garcia-Closas, M, Jones, M, Krogh, V, Lund, E, Masala, G, Mattiello, A, Orr, N, Palli, D, Panico, S, Polidoro, S, Sacerdote, C, Sandanger, T, Severi, G, Swerdlow, A, Tomczyk, K, Tumino, R, van veldhoven, K, vineis, P   +25 more
core   +5 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Stress related epigenetic changes may explain opportunistic success in biological invasions in Antipode mussels [PDF]

, 2018
Different environmental factors could induce epigenetic changes, which are likely involved in the biological invasion process. Some of these factors are driven by humans as, for example, the pollution and deliberate or accidental introductions and others
A Ardura, A Ardura, A Brenkert, A Pecinka, A Pérez-Figueroa, A Salmon, A Zaiko, A Zemach, AB Nicotra, AG Marsh, AK Sakai, AL Liebl, AR Linde, B Bec, B Liu, BM Turner, BR Wilson, CE Braby, CE Lee, CL Richards, DH Lim, DJ Madariaga, DL Strayer, DM Updegraff, E Briski, E Malone, F Devloo-Delva, F Valladares, FJ Santaclara, FT Chan, G Riviere, I Pejovic, J Atalah, J Fulneček, JA Rusiecki, JC Rice, JH McDonald, JM Jones, K Gérard, KJF Verhoeven, KV Kardong, L Alessa, L Excoffier, L Manti, L Miralles, M Barbieri, MA Khadim, MB Vandegehuchte, MJ Lexer, MR Gavery, MR Gavery, O Bossdorf, O Broennimann, P Colosimo, P García-Fernández, P Moran, PA Gardner, PA Jones, R Alquezar, R Karan, R Peakall, R Peakall, R Tingley, RA Zerebecki, S Gofas, S Gollasch, S Pascual, SCH Barrett, SJ Bownes, T Kohama, TJ Hilbish, V Chinnusamy, V Suarez-Ulloa, Y Sun, Ø Hammer   +74 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics

Clinical Epigenetics, 2012
Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins.
Kubota Takeo, Miyake Kunio, Hirasawa Takae   +2 more
doaj   +1 more source

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources

The preconception environment and sperm epigenetics

Andrology, 2020
Infertility is a common reproductive disorder, with male factor infertility accounting for approximately half of all cases. Taking a paternal perceptive, recent research has shown that sperm epigenetics, such as changes in DNA methylation, histone ...
Chelsea Marcho, Oladele A. Oluwayiose, J. Pilsner   +2 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology

Current Issues in Molecular Biology
Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and ...
Wan Ying Tan, Snigdha Nagabhyrava, Olivia Ang-Olson, Paromita Das, Luisa Ladel, Bethsebie Sailo, Linda He, Anup Sharma, Nita Ahuja   +8 more
doaj   +1 more source

Epigenetics and aging

Science Advances, 2016
Researchers review how random changes and our environment (for example, diet) determines our life span. Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing ...
Sangita Pal, J. Tyler
semanticscholar   +1 more source