Results 201 to 210 of about 175,170 (271)

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Correction: TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination. [PDF]

J Exp Clin Cancer Res
Zhou Q, Chen X, Yao K, Zhang Y, He H, Huang H, Chen H, Peng S, Huang M, Cheng L, Zhang Q, Xie R, Li K, Lin T, Huang H.   +14 more
europepmc   +1 more source

Cancer epigenetics takes center stage [PDF]

, 2001
Andrew P. Feinberg
openalex   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

The Complete Genome Sequence of the Moroccan endemic plant <i>Artemisia ifranensis</i> (Asteraceae, Asterales). [PDF]

Biodivers Genomes
Samlali HM, El Ghoubali D, Bennani B, Bari A, Pirro S, Idrissi AA, Ghazal H.   +6 more
europepmc   +1 more source

Epigenetic and experimental modifications in early mammalian development: Part I: Mitochondria: potential roles in embryogenesis and nucleocytoplasmic transfer [PDF]

, 2001
Jennifer Cummins
openalex   +1 more source

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Advanced Science, EarlyView.
This study explores the role of gemcitabine (GEM)‐resistant pancreatic cancer‐derived extracellular vesicles (EVs) in activating pancreatic stellate cells (PSCs) and promoting extracellular matrix production. GEM‐resistant cells release higher levels of asparagine (Asn), which triggers PSC activation. Long noncoding RNA sequencing identified linc‐ZNF25‐
Miao Yu, Mingxin Su, Zhenfeng Tian, Lele Pan, Zongmeng Li, Enlai Huang, Yinting Chen   +6 more
wiley   +1 more source

Caenorhabditis Elegans as a Model for Environmental Epigenetics. [PDF]

Curr Environ Health Rep
Filipowicz A, Allard P.
europepmc   +1 more source

Epigenetic silencing of PEG3 gene expression in human glioma cell lines* [PDF]

, 2001
Shinji Maegawa, Hirotaka Yoshioka, Noriko Itaba, Norika Kubota, Shigeki Nishihara, Yasuaki Shirayoshi, Eiji Nanba, Mitsuo Oshimura   +7 more
openalex   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source