Results 221 to 230 of about 224,057 (304)

Breastfeeding association with DNA methylation in the pregnancy and childhood epigenetics (PACE) consortium. [PDF]

Clin Epigenetics
Caramaschi D, Fernández-Barrés S, Casey E, Cruells A, Czamara D, Sharkawy ME, Elliott HR, Fore R, Gairola R, Gruzieva O, Huels A, Lahti J, Lee H, Magnano San Lio R, Malmberg A, Mansell T, Merid SK, Novakovic B, Ott R, Pelegrí D, Rezwan FI, Rifas-Shiman SL, Weiss A, de Lauzon-Guillain B, Duijts L, Grote V, Holloway JW, Koen N, Relton CL, Stein DJ, Zar HJ, Braun JM, Cecil KM, Hivert MF, Hummel S, Jaddoe VWV, Karachaliou Μ, Karmaus W, Kogevinas M, Koletzko B, Kull I, Melén E, Oken E, Räikkönen K, Saffery R, Vrijheid M, Wright J, Yolton K, Heude B, Felix JF, Bustamante M.   +50 more
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies. [PDF]

Proc Nutr Soc
Godfrey KM, Costello P, El-Heis S.
europepmc   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Astrocyte epigenetics as a priority area in neuroscience research. [PDF]

Front Mol Neurosci
Morales Pantoja IE, Mintz CD.
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Epigenetics and chemical exposures. [PDF]

Essays Biochem
Córdova-Casanova A, Ozanne SE.
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Commentary: Novel mtDNA methylation-associated prognostic signatures in colorectal cancer. [PDF]

Front Oncol
Jiang X, Zhang X, Wang M.
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source