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Epigenetics in hepatocellular carcinoma.
Seminars in Cancer Biology, 2021Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC.
G. Nagaraju +4 more
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Neurochemistry International, 2021
Substance use disorders are complex biopsychosocial disorders that have substantial negative neurocognitive impact in various patient populations. These diseases involve the compulsive use of licit or illicit substances despite adverse medicolegal consequences and appear to be secondary to long-lasting epigenetic and transcriptional adaptations in ...
Jean Lud, Cadet, Subramaniam, Jayanthi
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Substance use disorders are complex biopsychosocial disorders that have substantial negative neurocognitive impact in various patient populations. These diseases involve the compulsive use of licit or illicit substances despite adverse medicolegal consequences and appear to be secondary to long-lasting epigenetic and transcriptional adaptations in ...
Jean Lud, Cadet, Subramaniam, Jayanthi
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Nature Biotechnology
Epigenetics is the study of heritable changes to the genome and gene expression patterns that are not caused by direct changes to the DNA sequence. Examples of these changes include posttranslational modifications to DNA-bound histone proteins, DNA methylation, and remodeling of nuclear architecture.
Rajan, Jain, Jonathan A, Epstein
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Epigenetics is the study of heritable changes to the genome and gene expression patterns that are not caused by direct changes to the DNA sequence. Examples of these changes include posttranslational modifications to DNA-bound histone proteins, DNA methylation, and remodeling of nuclear architecture.
Rajan, Jain, Jonathan A, Epstein
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Epigenetics in NAFLD/NASH: Targets and Therapy.
Pharmacological Research, 2021Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific attention, owing to its rapid increase in prevalence worldwide and growing burden on end-stage liver diseases.
Nalini Sodum +4 more
semanticscholar +1 more source
Maturitas, 2013
Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks,
D'Aquila P +3 more
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Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks,
D'Aquila P +3 more
openaire +2 more sources
The Key Role of Epigenetics in Human Disease Prevention and Mitigation
New England Journal of Medicine, 2018Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene expression through alterations in DNA or associated factors (other than the DNA sequence). These factors control the diverse manifestations of diseases.
A. Feinberg
semanticscholar +1 more source
Epigenetics and atherosclerosis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009The contribution of epigenetic mechanisms to cardiovascular diseases remains poorly understood. Hypomethylation of genomic DNA is present in human atherosclerotic lesions and methylation changes also occur at the promoter level of several genes involved in the pathogenesis of atherosclerosis, such as extracellular superoxide dismutase, estrogen ...
Mikko P, Turunen +2 more
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2021
Aggression is a complex behavioral trait modulated by both genetic and environmental influences on gene expression. By controlling gene expression in a reversible yet potentially lasting manner in response to environmental stimulation, epigenetic mechanisms represent prime candidates in explaining both individual differences in aggression and the ...
Florian, Duclot, Mohamed, Kabbaj
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Aggression is a complex behavioral trait modulated by both genetic and environmental influences on gene expression. By controlling gene expression in a reversible yet potentially lasting manner in response to environmental stimulation, epigenetic mechanisms represent prime candidates in explaining both individual differences in aggression and the ...
Florian, Duclot, Mohamed, Kabbaj
openaire +2 more sources
Psychiatry Research, 2021
Schizophrenia (SCZ) is a chronic psychotic disorder that contributes significantly to disability, affecting behavior, thought, and cognition. It has long been known that there is a heritable component to schizophrenia; studies in both the pre-genomic and post-genomic era, however, have failed to elucidate fully the genetic basis for this complex ...
Anil, Srivastava +7 more
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Schizophrenia (SCZ) is a chronic psychotic disorder that contributes significantly to disability, affecting behavior, thought, and cognition. It has long been known that there is a heritable component to schizophrenia; studies in both the pre-genomic and post-genomic era, however, have failed to elucidate fully the genetic basis for this complex ...
Anil, Srivastava +7 more
openaire +2 more sources
Pancreatology, 2007
'Epigenetics', the term that is used for the study of heritable changes in gene function that occur without a change in the DNA sequence, has become a significant area of research. As a consequence of this emerging field, our concepts founded upon genetics alone have been blurred and the way researchers think about heredity has changed.
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'Epigenetics', the term that is used for the study of heritable changes in gene function that occur without a change in the DNA sequence, has become a significant area of research. As a consequence of this emerging field, our concepts founded upon genetics alone have been blurred and the way researchers think about heredity has changed.
openaire +2 more sources