Results 271 to 280 of about 369,301 (351)

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Accelerated Epigenetic Aging and Its Role in Brain Dynamics and Cognition in Young Adulthood. [PDF]

Hum Brain Mapp
Jordánek T, Mareček R, Pačínková A, Andrýsková L, Brázdil M, Marečková K.   +5 more
europepmc   +1 more source

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

, 2001
David G. Burbee, Éva Forgács, Sabine Zöchbauer‐Müller, Latha Shivakumar, Kwun M. Fong, Bo Gao, Dwight E. Randle, Masashi Kondo, A K Virmani, S. Bader, Yoshitaka Sekido, Farida Latif, Sara Milchgrub, Shinichi Toyooka, Adi F. Gazdar, M.I. Lerman, Eugene R. Zabarovsky, Michael A. White, J D Minna   +18 more
openalex   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure. [PDF]

Clin Epigenetics
Gemmati D, Scarpellini F, Salvatori F, D'Aversa E, Marci R, Capucci R, Antonica B, Grisafi M, Turato E, Vargas JV, Secchiero P, Zauli G, Singh AV, Tisato V.   +13 more
europepmc   +1 more source

The VERNALIZATION 2 Gene Mediates the Epigenetic Regulation of Vernalization in Arabidopsis

, 2001
Anthony R. Gendall, Yaron Y. Levy, Allison Wilson, Caroline Dean   +3 more
openalex   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

From genetic to postgenomic determinisms: The role of the environment reconsidered : Introduction to the collection 'Postgenomic determinisms: Environmental narratives after the century of the gene'. [PDF]

Hist Philos Life Sci
Chellappoo A, Baedke J, Meloni M.
europepmc   +1 more source