Results 281 to 290 of about 475,691 (380)

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Correction: Artificial intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine. [PDF]

Epigenetics Chromatin
Sahoo K, Lingasamy P, Khatun M, Sudhakaran SL, Salumets A, Sundararajan V, Modhukur V.   +6 more
europepmc   +1 more source

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

, 2000
Stephen B. Baylin, James G. Herman
openalex   +1 more source

Epigenetic silencing of the tumor-suppressing gelsolin gene involves histone deacetylation of its promoter region in human urinary bladder cancer [PDF]

, 2001
Kazunori Haga, Hisakazu Fujita, Ataru Sazawa, Masato Takimoto, Nobuo Shinohara, Tomohiko Koyanagi, Noboru Kuzumaki   +6 more
openalex   +1 more source

Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends

Advanced Science, EarlyView.
This systematic scoping review explores conductive nanocomposite hydrogels for neural tissue engineering(NTE), focusing on composition, cellular interactions, and neural differentiation capabilities. The review synthesizes data from 125 studies, examining important features including commonly used materials, cell types, and differentiation strategies ...
Mohammad Moghaddasi, Busra Oktay, Ayse Betul Bingol, Reyhan Yanikoglu, Meryem Muslu, Ibrahim T Ozbolat, Cem Bulent Ustundag   +6 more
wiley   +1 more source

RETRACTED: Sibuh et al. The Emerging Role of Epigenetics in Metabolism and Endocrinology. <i>Biology</i> 2023, <i>12</i>, 256. [PDF]

Biology (Basel)
Sibuh BZ, Quazi S, Panday H, Parashar R, Jha NK, Mathur R, Jha SK, Taneja P, Jha AK.   +8 more
europepmc   +1 more source

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source

Epigenetic control of the plant metabolome: implications for Chinese medicine. [PDF]

Chin Med
Hyun TK.
europepmc   +1 more source

Establishment of an oriP Replicon Is Dependent upon an Infrequent, Epigenetic Event [PDF]

, 2001
Elizabeth R. Leight, Bill Sugden
openalex   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source