Results 191 to 200 of about 93,647 (322)

Introducing the EpG² System: Epigenomic Processes and the Emergent Genome. [PDF]

Epigenomes
Ruiz-Narváez EA.
europepmc   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Editorial: Aging epigenome and longevity. [PDF]

Front Aging
Singh SK, Poeggeler B.
europepmc   +1 more source

Epigenome-wide association study meta-analysis of BMI in African American Adults [PDF]

Kendra Ferrier, M. Graff, Iain R. Konigsberg, Maggie A. Stanislawski, Heather M. Highland, Laura M. Raffield, April P. Carson, Eric Boerwinkle, Jill M. Norris, Christopher R. Gignoux, Audrey E. Hendricks, Sridharan Raghavan, Kari E. North, Matthew Allison, Matthew J. Budoff, Silva Kasela, François Aguet, Joshua J. Joseph, Charles Kooperberg, Stephen S. Rich, Jerome I. Rotter, Ethan M. Lange, Leslie A. Lange   +22 more
openalex   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source

Advances in Colorectal Cancer Cell Biology and Clonal Evolution. [PDF]

Int J Mol Sci
Toghey S, Harvey-Jones EJ, Towler JD, Hafkamp CJH, Chong IY.   +4 more
europepmc   +1 more source

Association Between Abnormal DNA Methylation and Altered Transcriptome in Muscle Five Years After Critical Illness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years. Recently, altered RNA expression was documented in muscle of former ICU patients 5 years after critical illness that suggested disrupted mitochondrial function, disturbed lipid metabolism and fibrosis, of which ...
Ceren Uzun Ayar, Fabian Güiza, Inge Derese, Greet Van den Berghe, Ilse Vanhorebeek   +4 more
wiley   +1 more source

Epigenome-wide analysis identifies DNA methylation signatures associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism. [PDF]

Sci Rep
Fish LA, Gliga T, Gui A, Ali JB, Mason L, Johnson MH, Charman T, Falck-Ytter T, Jones EJH, Kandaswamy R, Happé F, Wong CCY.   +11 more
europepmc   +1 more source

Pan‐Epigenetic Age Prediction in Mammals

Aging Cell, Volume 25, Issue 2, February 2026.
Across > 1000 human and mouse epigenomes, histone modifications and DNA methylation undergo coordinated, cross‐tissue remodeling at shared genes. ABSTRACT Epigenetic remodeling is a hallmark of aging, yet which epigenetic layers are most affected during aging—and the extent to which they are interrelated—is not well understood.
Zane Koch, Adam Li, Trey Ideker
wiley   +1 more source

Epigenetics and chemical exposures. [PDF]

Essays Biochem
Córdova-Casanova A, Ozanne SE.
europepmc   +1 more source