Recent advances in methodologies of epigenomics. [PDF]
EpigenomicsOhishi H, Au Yeung WK.
europepmc +1 more source
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins. [PDF]
Nat CommunXu D +13 more
europepmc +1 more source
Targeted in vivo epigenome editing of H3K27me3 [PDF]
, 2019 Hiroto Fukushima +2 more
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Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Opposite aging effects among cell subsets revealed in the human transcriptome and epigenome. [PDF]
MicroPubl BiolOkada D.
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Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells [PDF]
, 2014 Armelle Corpet, Manuel Stucki
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Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
Mitochondrial DNA copy number reduction via <i>in vitro TFAM</i> knockout remodels the nuclear epigenome and transcriptome. [PDF]
EpigenomicsWin PW +13 more
europepmc +1 more source