Results 281 to 290 of about 93,647 (322)

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source

Ageing versus developmental silencing: Answers from the epigenome. [PDF]

FEBS J
Sadler KC, Storer MA, Bayin NS.
europepmc   +1 more source

Bivalent Histone Modifications Orchestrate Temporal Regulation of Glucosinolate Biosynthesis During Wound‐Induced Stress Responses in Arabidopsis

Plant, Cell &Environment, Volume 49, Issue 1, Page 450-473, January 2026.
ABSTRACT Glucosinolates (GSLs) are secondary metabolites central to plant defence in the Brassicaceae family. While the role of histone modifications in developmental gene regulation is well studied, their function in stress‐induced secondary metabolism remains unclear.
Dasom Choi, Sang Woo Lee, Dong‐Hwan Kim   +2 more
wiley   +1 more source

Multi-omics analyses identify potential epigenetic loci associated with survival in amyotrophic lateral sclerosis across diverse populations. [PDF]

EBioMedicine
Gu Y, Chen Y, Tang X, Guo J, Hu J, Yang W, Li J, Chen X, Fan D, Chen GB, He J, Ren Y, Dong Y, Sato C, Chen Y, Zinman L, Rogaeva E, Zhang M.   +17 more
europepmc   +1 more source

Prognostically Significant Glycan Profiles of Clear Cell Renal Cell Carcinoma Identified by Integrated Glycome–Methylome Analysis

Pathology International, Volume 76, Issue 1, January 2026.
Comprehensive glycomics analysis and genome‐wide DNA methylation analysis using tissue samples of clear cell renal cell carcinoma (ccRCC) have revealed that the glycan profile, including “immature” N‐type glycans, may be attributable to epigenetic regulation of glycogenes.
Yoshiko Kitazume, Eri Arai, Mao Fujimoto, Kentaro Ohara, Atsushi Matsuda, Shuichi Kakuda, Hiroyuki Fujimoto, Akiko Miyagi Maeshima, Nobuyoshi Hiraoka, Teruhiko Yoshida, Atsushi Kuno, Yae Kanai   +11 more
wiley   +1 more source

Exploring the association between DNA methylation and pancreatic cancer susceptibility through epigenome-wide Mendelian randomization and multi-omics data integration. [PDF]

Epigenetics
Wang P, Rong F, Liu F.
europepmc   +1 more source

Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes

Ahmad Salman Sirajee, Debajyoti Kabiraj, Subhajyoti De   +2 more
openalex   +1 more source

Genotype‐dependent DNA methylation patterns are negatively associated with allelic variation rather than heat‐induced gene expression in two contrasting potato genotypes

The Plant Journal, Volume 125, Issue 2, January 2026.
SUMMARY Potato (Solanum tuberosum L.) is an important food crop that is sensitive to high temperatures, which cause major changes in the transcriptome and a reduction in yield. In several plant species, DNA methylation has been reported to influence gene expression, particularly under abiotic stress conditions.
Darren Sheng Gin Yeo, Julia Eydam, Julien Bruckmüller, Friedrich Kauder, Jens Lübeck, Alexander Kaier, Sophia Sonnewald, Uwe Sonnewald   +7 more
wiley   +1 more source

Medical Marijuana and Treatment Personalization: The Role of Genetics and Epigenetics in Response to THC and CBD. [PDF]

Genes (Basel)
Kalak M, Brylak-Błaszków A, Błaszków Ł, Kalak T.   +3 more
europepmc   +1 more source

Early Nutritional Programing: Unlocking the Potential of Fish for Sustainable Aquaculture

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Nutritional programing, which explores the link between early nutritional conditions and their long‐term effects on animals, is a developing field within fish biology. Suboptimal nutritional status during early life is strongly associated with a higher risk of metabolic consequences later in life, including permanent growth retardation, impaired neural
Shivendra Kumar, Aditi Banik, Maneesh Kumar Dubey, Prem Prakash Srivastava, Zsuzsanna J. Sandor, Jianguang Qin   +5 more
wiley   +1 more source