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The Concepts of Epigenomics and Cell Epigenomes
2022Genetics cannot solely explain genetic variations in humans and disease developments. We see varying differences in phenotypes and disease susceptibility in organisms that have the same genetic make-up, e.g., monozygotic twins and cloned animals.
Daştan, Taner, Baral, İnanç
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2007
Epigenomics or epigenetics refers to the modification of DNA that can influence the phenotype through changing gene expression without altering the nucleotide sequence of the DNA. Two examples are methylation of DNA and acetylation of the histone DNA-binding proteins. Dietary components - both nutrients and nonnutrients - can influence these epigenetic
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Epigenomics or epigenetics refers to the modification of DNA that can influence the phenotype through changing gene expression without altering the nucleotide sequence of the DNA. Two examples are methylation of DNA and acetylation of the histone DNA-binding proteins. Dietary components - both nutrients and nonnutrients - can influence these epigenetic
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Trends in Plant Science, 2008
Recent studies of plant development and environmental stress responses have converged on the roles of RNA and its metabolism as primary regulators of gene action. This RNA-based system appears to represent a versatile platform both for maintaining epigenetic memory and for reprogramming gene control in response to external signals.
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Recent studies of plant development and environmental stress responses have converged on the roles of RNA and its metabolism as primary regulators of gene action. This RNA-based system appears to represent a versatile platform both for maintaining epigenetic memory and for reprogramming gene control in response to external signals.
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Characterizing cis-regulatory elements using single-cell epigenomics
Nature reviews genetics, 2022Sebastian Preissl, K. Gaulton, B. Ren
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Personalized Medicine, 2006
Earlier diagnosis and a more individualized choice of treatment options has the potential to greatly improve the outcome of life-threatening diseases. DNA methylation has proven to be a rich source of biomarkers for diagnosis, prognosis and drug response prediction in cancer and other diseases.
Christoph, Sachsenmaier, Achim, Plum
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Earlier diagnosis and a more individualized choice of treatment options has the potential to greatly improve the outcome of life-threatening diseases. DNA methylation has proven to be a rich source of biomarkers for diagnosis, prognosis and drug response prediction in cancer and other diseases.
Christoph, Sachsenmaier, Achim, Plum
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2012
Epigenetic regulation is central to genome structure and function. Epigenetic status varies between individuals, and there is increasing awareness of the importance of this variation in health and disease. Epigenetic mechanisms include DNA methylation, histone modification, and regulation by noncoding RNAs.
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Epigenetic regulation is central to genome structure and function. Epigenetic status varies between individuals, and there is increasing awareness of the importance of this variation in health and disease. Epigenetic mechanisms include DNA methylation, histone modification, and regulation by noncoding RNAs.
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Neuropsychobiology, 2009
It is not known whether and how epigenetic factors contribute to the pathophysiology of mental disorders. As possible mechanisms, epimutations during embryogenesis, epigenetic memory of environmental effects, and the role of epigenetic gene regulation in the action mechanisms of treatment may be considered.
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It is not known whether and how epigenetic factors contribute to the pathophysiology of mental disorders. As possible mechanisms, epimutations during embryogenesis, epigenetic memory of environmental effects, and the role of epigenetic gene regulation in the action mechanisms of treatment may be considered.
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2010
Cancer is a heterogeneous disease caused largely by abnormalities of the genome and the epigenome. Typically, such abnormalities include genetic changes such as mutations and other genomic rearrangements or epigenetic changes such as aberrant DNA methylation and histone modifications that are frequently mediated by exposure to environmental or ...
Chris Boshoff +2 more
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Cancer is a heterogeneous disease caused largely by abnormalities of the genome and the epigenome. Typically, such abnormalities include genetic changes such as mutations and other genomic rearrangements or epigenetic changes such as aberrant DNA methylation and histone modifications that are frequently mediated by exposure to environmental or ...
Chris Boshoff +2 more
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2011
The development of male germ cells from the primordial germ cell stage to that of the mature spermatozoon is a key time of epigenetic reprogramming. Orchestrated by specialized enzymes, DNA methylation and histone modifications undergo dynamic changes throughout gametogenesis. Alterations to any level of the sperm epigenetic coding may affect fertility
Jacquetta M. Trasler, Donovan Chan
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The development of male germ cells from the primordial germ cell stage to that of the mature spermatozoon is a key time of epigenetic reprogramming. Orchestrated by specialized enzymes, DNA methylation and histone modifications undergo dynamic changes throughout gametogenesis. Alterations to any level of the sperm epigenetic coding may affect fertility
Jacquetta M. Trasler, Donovan Chan
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