Results 321 to 330 of about 52,554 (369)

Immigrant status and citizenship relationships with epigenetic aging in a representative sample of United States adults. [PDF]

Epigenomics
Nwanaji-Enwerem JC, Rodriguez Espinosa P, Khodasevich D, Gladish N, Shen H, Bozack AK, Daredia S, Needham BL, Rehkopf DH, Cardenas A.   +9 more
europepmc   +1 more source

Fibroblasts‐specific p16INK4a exacerbates inflammageing‐mediated post‐infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
In ageing fibroblasts, p16INK4a concurrently enhanced STAT3 di‐methylation mediated by EZH2 and suppressed the assembly of Bmi‐1‐EZH2/BCL‐6 complexes at the NLRP3 promoter region. These dual regulatory actions synergistically upregulated STAT3‐dependent NLRP3 transcription, thereby exacerbating inflammageing‐driven ventricular remodelling following ...
Xin Gu, Yingqiang Du, Jin'ge Zhang, Jiyu Li, Haiyun Chen, Yujie Lin, Yue Wang, Chunli Zhang, Shiyu Lin, Nannan Hao, Chengyi Peng, Jiacheng Ge, Jin Liu, Yan Liang, Yongjie Zhang, Xiaoyan Wang, Fang Wang, Jianliang Jin   +17 more
wiley   +1 more source

Butyrate Selectively Targets Super‐Enhancers and Transcriptional Networks Associated with Human Mast Cell Function

European Journal of Immunology, Volume 55, Issue 6, June 2025.
Butyrate, a short‐chain fatty acid (SCFA) derived from dietary fibers, selectively inhibits human mast cell activation by targeting transcription start sites (TSS) and super‐enhancers regulating key mast cell genes. Local histone hypoacetylation induced by butyrate likely drives transcriptional suppression and reduced degranulation, providing new ...
Jelle Folkerts, Marjolein J. W. de Bruijn, Wilfred F. J. van IJcken, Rudi W. Hendriks, Ralph Stadhouders   +4 more
wiley   +1 more source

Epigenomics coverage data extraction and aggregation in R with tidyCoverage. [PDF]

Bioinformatics
Serizay J, Koszul R.
europepmc   +1 more source

Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value. [PDF]

Front Oncol
Hattori N, Takamatsu H, Iida N, Asano N, Yamashita S, Oba GM, Kimura K, Yoshida A, Kobayashi E, Nakayama R, Matsumoto M, Nakamura M, Kawai A, Ushijima T.   +13 more
europepmc   +1 more source

Epigenomics and the Brain-gut Axis: Impact of Adverse Childhood Experiences and Therapeutic Challenges. [PDF]

J Transl Gastroenterol
Wiley JW, Higgins GA.
europepmc   +1 more source

Identification of a chromatin regulator signature and potential candidate drugs for primary open-angle glaucoma. [PDF]

Epigenomics
Zhang X, Xiao L, Zhou X, Xu J, Liao L, Wu P, Liao Z, Duan X.   +7 more
europepmc   +1 more source

A multiomics dataset of paired CT image and plasma cell-free DNA end motif for patients with pulmonary nodules. [PDF]

Sci Data
Zhao M, Xue G, He B, Deng J, Wang T, Zhong Y, Li S, Wang Y, He Y, Chen T, Zhang J, Yan Z, Hu X, Guo L, Qu W, Song Y, Yang M, Zhao G, Yu B, Ma M, Liu L, Sun X, Zhao D, Xie D, Chen C, She Y.   +25 more
europepmc   +1 more source