Results 91 to 100 of about 113,968 (310)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Relationship Between Medication Adherence and Prospective Memory in Individuals with Epilepsy

Archives of Epilepsy
Objective: Epilepsy is a condition characterized by sudden, recurrent epileptic seizures that occur as a result of abnormal and excessive electrical discharge in cortical neurons and are not triggered by an identifiable event.
Ece Hilal, Yağmur Uluhan, Serkan Aksu, Semai Bek, Gülnihal Kutlu   +4 more
doaj   +1 more source

Genetic Variation in Calcium Channel Gene in Idiopathic Generalized Epilepsies

Pediatric Neurology Briefs, 2008
Researchers at Women's And Children's Hospital, North Adelaide, and other centers in Australia and Canada screened 240 individuals from 167 families with idiopathic generalized epilepsy and generalized epilepsy with febrile seizures plus (GEFS + ) and 95
J Gordon Millichap
doaj   +1 more source

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo, Di Giovanni, Giuseppe, Errington, Adam C.   +2 more
core  

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Statins' protective effects on focal epilepsy are independent of LDL‐C

Epilepsia Open
Objective This study evaluates the potential protective effects of statins against epilepsy, focusing on their differential impacts on focal and generalized epilepsy.
Zhen Sun, Jing Zhang, Yulong Li, Miao Tuo, Limin Yu, Yun Wang, Yanping Sun   +6 more
doaj   +1 more source

Seizure control in patients with epilepsy: the physician vs. medication factors [PDF]

, 2008
Background Little is known about the relationship between types of healthcare providers and outcomes in patients with epilepsy. This study compares the relative effects of provider type (epileptologist vs.
Jerzy P Szaflarski, Angela Y Rackley, Christopher J Lindsell, Magdalena Szaflarski, Stephen L Yates, MR Nuwer, MR Nuwer, A Catlin, AMSA, J Macinko, JZ Ayanian, JB Mitchell, A Arain, DM Ficker, WA Hauser, D Sopelana, P Seenan, N Diaz, R Kobau, K Poole, P Bradley, O Devinsky, F Gilliam, JP Szaflarski, JP Szaflarski, JO Elliott   +25 more
core   +2 more sources

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

CONSANGUINEOUS MARRIAGE AS RISK FACTOR FOR IDIOPATHIC GENERALIZED EPILEPSY (IGE)

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the significance of parental consanguinity as a risk factor for idiopathic generalized epilepsies. Study Design: Case control study.
Shumaila Rafique, Tipu Sultan, Shabir Ahmed   +2 more
doaj  

Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies [PDF]

, 2017
Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary ...
Cartwright, Karen, Formerly: Eisai Ltd., Kwan, Patrick, Laurenza, Antonio, Mintzer, Scott, Patten, Anna   +5 more
core   +1 more source