Results 161 to 170 of about 974,404 (311)

THE GENERALIZED EPILEPSIES [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1973
openaire   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Refining the electroclinical phenotype of 15q11.2 microdeletion: EEG biomarker overlap with Angelman syndrome

Epileptic Disorders, EarlyView.
Abstract The 15q11.2 microdeletion is a chromosomal condition associated with a broad epileptic phenotype. It is differentiated from Angelman syndrome, which is typically a larger maternal deletion in an overlapping area. We describe a patient with a 15q11.2 microdeletion that has clinical and EEG biomarker features similar to those seen in Angelman ...
Hok Leong Chin, Joshua Chang, Douglas Nordli III   +2 more
wiley   +1 more source

Does variation in NIPA2 contribute to genetic generalized epilepsy?

, 2014
Does variation in NIPA2 contribute to genetic generalized ...
Michael S Hildebrand (10688811), Susannah T Bellows (15888839), Ingrid E Scheffer (10577391), John A Damiano (10688784), Saul A Mullen (13602007), Samuel F Berkovic (10577323)   +5 more
core  

Peripheral inflammatory markers and metabolic profiles in temporal lobe epilepsy and functional dissociative seizures

Epileptic Disorders, EarlyView.
Abstract Background Temporal lobe epilepsy (TLE) and functional dissociative seizures (FDS) are distinct conditions that share overlapping clinical, neuropsychiatric, and biological features, including depressive symptoms, obesity‐related metabolic dysregulation, and alterations in systemic inflammatory markers.
Betül Merd, Şeyma Benli, Fatmanur Merd, İnayet Güntürk, Cevat Yazici, Meltem Sönmez, Füsun Ferda Erdoğan   +6 more
wiley   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Epileptic Disorders, EarlyView.
Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity ...
Ionuț‐Flavius Bratu, Agnès Trébuchon, Fabrice Bartolomei   +2 more
wiley   +1 more source