Results 121 to 130 of about 133,415 (261)

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Can we predict surgical outcomes: A systematic review and critical appraisal of clinical prediction models in epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective Prediction models are increasingly being sought in epilepsy surgery to predict postoperative outcomes and support clinical decision‐making. Studies summarizing the evidence in this area can provide insight into the type of surgical prediction models, their methodology, and their performance and inform areas for future research.
Alyssa A. Federico, Mandavi Kashyap, Chantelle Q. Y. Lin, Karl M. Klein, Olayinka I. Arimoro, Samuel Wiebe   +5 more
wiley   +1 more source

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil, Margaret M. Donahue, Cathy B. Dang, Gergely Tarcsay, Laura A. Ewell   +4 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

No link between piriform cortex subregion resection and seizure freedom in two cohorts with temporal lobe epilepsy. [PDF]

J Neurol
Zahnert F, Pfanzelt F, Menzler K, Habermehl L, Keil B, Timmermann L, Kemmling A, Grote A, Nimsky C, Knake S, Belke M.   +10 more
europepmc   +1 more source

Disrupted dynamic network reconfiguration of the language system in temporal lobe epilepsy

Brain : a journal of neurology, 2018
Xiaosong He, D. Bassett, G. Chaitanya, M. Sperling, Lauren Kozlowski, J. Tracy   +5 more
semanticscholar   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Direct cortical stimulation-evoked symptoms in the human temporal pole: a cohort study. [PDF]

Clin Neurophysiol Pract
Novitskaya Y, Schulze-Bonhage A.
europepmc   +1 more source

Picture naming: Stereoelectroencephalography and connectivity insights

Epilepsia, EarlyView.
Abstract Objective This study investigates the neural substrates of picture naming (PN) using stereoelectroencephalographic (SEEG) stimulations and evaluates the contribution of white matter (WM) fascicles related to the basal temporal language area (BTLA) to the broader functional PN network.
Insafe Mezjan, Fabien Rech, Olivier Aron, Louis Maillard, Sophie Colnat‐Coulbois   +4 more
wiley   +1 more source

Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial

Epilepsia, 2018
N. Barbaro, M. Quigg, Mariann M. Ward, E. Chang, D. Broshek, J. Langfitt, G. Yan, K. Laxer, A. Cole, P. Sneed, C. Hess, Wei Yu, M. Tripathi, C. Heck, John W. Miller, P. Garcia, A. McEvoy, N. Fountain, V. Salanova, R. Knowlton, A. Bagić, T. Henry, S. Kapoor, G. Mckhann, Adriana E. Palade, M. Reuber, E. Tecoma   +26 more
semanticscholar   +1 more source