Results 71 to 80 of about 2,852,642 (351)

Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation—A Case Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT New‐onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%–27% mortality rate and significant long‐term neurological sequelae. Neuromodulation such as deep brain stimulation (DBS) targeting the anterior and centromedian thalamic nuclei has shown promise when the traditional ...
Mengxuan Tang, Amerta Bai, Felipe Rodridgues Marques Ferreira, Sandipan Pati, Thaddeus Walczak, Benjamin Miller, Oladi Bentho, Thomas Henry, Ilo Leppik, Minoo Shams, Zhiyi Sha, Zachary Sanger, Theoden I. Netoff, Thomas Lisko, Anant Naik, Robert McGovern III, Sima Patel   +16 more
wiley   +1 more source

Implications of genetic diagnostics in epilepsy surgery candidates: A single‐center cohort study

Epilepsia Open, 2019
Genetic causes are increasingly identified in patients with focal epilepsy. These genetic causes may be related to the effectiveness of epilepsy surgery.
Maurits W C B Sanders, Cynthia M C Lemmens, F. Jansen, E. Brilstra, B. Koeleman, K. Braun   +5 more
semanticscholar   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Efficacy and Safety of Epilepsy Surgery for Older Adult Patients with Refractory Epilepsy

Therapeutics and Clinical Risk Management, 2020
Naoki Ichikawa, Ayataka Fujimoto, Tohru Okanishi, Keishiro Sato, Hideo Enoki Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, 430-8558, JapanCorrespondence: Ayataka FujimotoSeirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi ...
Ichikawa N, Fujimoto A, Okanishi T, Sato K, Enoki H   +4 more
doaj  

Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We estimated the statistical power of studies predicting seizure freedom after epilepsy surgery. We extracted data from a Cochrane meta‐analysis. The median power across all studies was 14%. Studies with a median sample size or less (n ≤ 56) and a statistically significant result exaggerated the true effect size by a factor of 5.4, while the ...
Adam S. Dickey, Vineet Reddy, Ammar A. Rashied, Nigel P. Pedersen, Robert T. Krafty   +4 more
wiley   +1 more source

Referral to evaluation for epilepsy surgery: Reluctance by epileptologists and patients

Epilepsia, 2019
Despite the obvious advantages of resective surgery in patients with drug‐resistant focal epilepsy, namely high probability of seizure freedom, decreased mortality, and increased quality of life, referral rates from physicians and approval rates by ...
M. Steinbrenner, A. Kowski, M. Holtkamp
semanticscholar   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Determinants of IQ outcome after focal epilepsy surgery in childhood: A longitudinal case‐control neuroimaging study

Epilepsia, 2019
Intelligence quotient (IQ) outcomes after pediatric epilepsy surgery show significant individual variation. Clinical factors such as seizure cessation or antiepileptic medication discontinuation have been implicated, but do not fully account for the ...
C. Skirrow, J. H. Cross, Rosie Owens, Louise J. Weiss-Croft, Patricia Martin‐Sanfilippo, T. Banks, Emily Shah, W. Harkness, F. Vargha-Khadem, T. Baldeweg   +9 more
semanticscholar   +1 more source

From In‐Silico Optimized Microfabrication to Experimental Validation: Engineering a Tridimensional Epi‐Intraneural Interface

Advanced Functional Materials, EarlyView.
An epi‐intraneural interface is developed through in silico optimization and a novel tridimensional microfabrication pipeline. The device integrates penetrating and epineural contacts on a flexible substrate. Mechanical, electrochemical, and in vivo testing in rat and pig reveal robust implantation, low‐threshold activation, and site‐dependent ...
Federico Ciotti, Andrea Cimolato, Noemi Gozzi, Pietro Palopoli, Luca Brugnoli, Natalija Katic Secerovic, Rebecca Gallivan, Alexander Shokurov, Carlo Menon, Johannes Weichart, Ignacio Delgado‐Martinez, Weiguo Song, Stavros Zanos, Xavier Navarro, Stanisa Raspopovic   +14 more
wiley   +1 more source

Testing an online screening tool for epilepsy surgery evaluation

Arquivos de Neuro-Psiquiatria
Background Epilepsy surgery is recognized for its effectiveness in controlling seizures in a significant number of patients with drug-resistant epilepsy.
Bianca Cecchele Madeira, Suzana Veiga Schönwald, Pablo Brea Winckler, Kelin Cristine Martin, Carolina Machado Torres, Jorge Wladimir Junqueira Bizzi, Marino Muxfeldt Bianchin   +6 more
doaj   +1 more source