Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures [PDF]
Epilepsia Open, 2022 Objective Among standard treatments for infantile spasms, adrenocorticotropic hormone (ACTH) is reported as the best treatment, but ACTH is ineffective in one‐half of the patients.
Yukitoshi Takahashi +14 more
doaj +3 more sources
Status Epilepticus Manifested as Continuous Epileptic Spasms [PDF]
Frontiers in Neurology, 2020 Objective: The etiology and outcome of status epilepticus with continuous epileptic spasms have not been fully understood; and only rare cases have been reported in the literature.
Jianxiang Liao +12 more
doaj +3 more sources
Epileptic Spasms in Congenital Disorders of Glycosylation [PDF]
Epileptic Disorders, 2017 Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, characterized by impaired glycosylation. Multisystemic involvement is common and neurological impairment is notably severe and disabling, concerning the central and ...
Bahi-Buisson, N +7 more
core +4 more sources
Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience. [PDF]
EpilepsiaAbstractObjectiveLead time to treatment (clinical onset of epileptic spasms [ES] to initiation of appropriate treatment) is known to predict outcomes in infantile epileptic spasms syndrome (IESS). Timing the clinical onset of ES is crucial to establish lead time. We investigated how often ES onset could be established to the nearest week.
Hadjinicolaou A +13 more
europepmc +5 more sources
Infantile epileptic spasms syndrome as a new phenotype in TOP2B deficiency caused by a <i>de novo</i> variant: a case report and literature review. [PDF]
Front PediatrZhu GQ, Yao Y, Yang LY, Hua Y, Li GM.
europepmc +3 more sources
First‐choice hormonal therapies for children with infantile epileptic spasms syndrome in South Asia: A network meta‐analysis of randomized controlled trials [PDF]
Epilepsia OpenConsidering the peculiar challenges with infantile epileptic spasms syndrome (IESS) in South Asia and a wide variation in the usage of hormonal therapies, we compared the efficacy and safety of various hormonal therapies for children with IESS in South ...
Nagita Devi +5 more
doaj +2 more sources
Ketogenic diet for infantile epileptic spasms
Epilepsia OpenAbstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS.
Morris H. Scantlebury +3 more
openaire +2 more sources
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms [PDF]
Epilepsia OpenObjective Infantile epileptic spasms (IS) are epileptic seizures that are associated with increased risk for developmental impairments, adult epilepsies, and mortality.
Ioana M. A. Samfira +5 more
doaj +2 more sources
New insights into epileptic spasm generation and treatment from the
Epilepsia Open, EarlyView.Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
openalex +2 more sources
Mean global field power is reduced in infantile epileptic spasms syndrome after response to vigabatrin. [PDF]
Front NeurolNair A +4 more
europepmc +3 more sources