Results 111 to 120 of about 21,587 (210)
Enantioselective Total Synthesis of (+)-Salvileucalin B [PDF]
, 2011 An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro ...
Levin, Sergiy +2 more
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Recent progress in the synthesis of six-membered aminocyclitols (2008-2017) [PDF]
, 2018 Aminocyclitols are of interest as glucosidase inhibitors, as probes for the study of pseudoglycosyltransferases, and as potential therapeutics for the treatment of Gaucher’s disease.
Donaldson, William
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Investigating the Intercarbonyl X...C' (X=O/S/N) Interactions in Short Peptides and Peptidomimetics. Evidence of charge->II* Interactions. Synthesis and Characterization of Thioimidate Isostere Containing Peptidomimetics [PDF]
, 2016 This thesis entitled “Investigating the Intercarbonyl X···C′ (X = O/S/N) Interactions in Short Peptides and Peptidomimetics. Evidence of Charge→π* Interactions. Synthesis and Characterization of Thioimidate Isostere Containing Peptidomimetics” is divided
Tumminakatti, Shama
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, 2013 International audienceSynthesis of 1,4-bis(oxazoline) ligands bearing a bicyclo[2,2,2]backbone derived from 9,10-dihydro-9,10-ethanoanthacene trans-dicarboxylic acid was revisited.
Dorcet, Vincent +2 more
core +3 more sources
Perspectives in protein and amino acid geochemistry [PDF]
, 2001 Resumen En este trabajo se presentan los avarices mas recientes en el uso de la geoqufmica de protefnas y aminoacidos. A pesar de que el empleo de la geoqui'mica de aminoacidos y protefnas para datacion disminuyo durante algunos anos.
Torres Pérez-Hidalgo, Trinidad José
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Production of constrained L-cyclo-tetrapeptides by epimerization-resistant direct aminolysis
Nature CommunicationsThe synthesis of constrained 12-membered rings is notably difficult. The main challenges result from constraints during the linear peptide cyclization. Attempts to overcome constraints through excessive activation frequently cause peptidyl epimerization,
Huan Chen +10 more
doaj +1 more source
ChemistryEuropeThe solventless synthesis of peptides from unactivated amino acids was optimized in a twin‐screw extruder (TSE). The general method enabled the preparation of dipeptides and tripeptides with no epimerization.
Dr. Tharwat Mohy El‐Dine +6 more
doaj +1 more source
Total Synthesis of Hapalosin and Its Analogues：Construction of Three Small Hapalosin C-9 Analogues Libraries and Studies on Total Synthesis of Melleumins A and B [PDF]
, 2007 环肽类化合物是一类结构复杂多样的天然产物。自然界中存在大量的环肽类化合物，表现出多种生物活性，如杀虫、抗菌、抗肿瘤、抗病毒、和免疫抑制等。环肽类化合物作为富有实用前景的先导化合物在药物发现中受到越来越多的关注，新的活性天然产物也不断被发现。同时，环肽类天然产物的全合成也成为不对称合成的新热点。Hapalosin(1a)是1994年从蓝藻中分离提取的一类新型结构的环肽化合物，因其对肿瘤细胞的多药耐药性细胞系有很强的抑制作用，一经发现就引起了广大合成化学家和药物化学家的关注。本论文的目标在于拓展手性合成砌块(
戴朝峰
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