Results 91 to 100 of about 13,012 (246)
Angewandte Chemie International Edition, EarlyView.An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner +5 more
wiley +1 more source
Epimerization of erythromycin derivatives.
The Journal of Antibiotics, 1990 Dirithromycin (3) isomerizes upon dissolution in different solvents. From X-ray analysis of V-T 108, an analogue of dirithromycin, and comparative 1H and 13C NMR, and MS data, the isomer of dirithromycin was confirmed to be the C-16-(S)-epimer. The ratio of the two epimers at equilibrium conditions was approximately 8:2 (R/S) in methanol at room ...
J, Firl +5 more
openaire +3 more sources
General and Scalable Amide Bond Formation with Epimerization-Prone Substrates Using T3P and Pyridine [PDF]
, 2016 The mild combination of T3P (n-propanephosphonic acid anhydride) and pyridine has been developed for low-epimerization amide bond formation and implemented for the synthesis of a key intermediate to a glucokinase activator.
Yanqiao Xiang (2010760) +3 more
core +1 more source
Chemistry – A European Journal, EarlyView.A sustainable route to photoresponsive molecular systems is achieved using the bio‐based flavanone (‐)‐isolonchocarpin from Tephrosia vogelii. Through McMurry homocoupling and light‐driven 6‐π‐electrocyclization, an overcrowded alkene and a fluorescent O‐heterocyclic phenanthrene are synthesized.
Deryl H. Limawan +8 more
wiley +1 more source
Epimerization and stereochemistry of avoparcin.
The Journal of Antibiotics, 1983 The epimerization of avoparcin entities is discussed in some detail. The absolute stereochemistry of avoparcin is now known since the N-methyl terminal amino acid of the aglycone has been isolated and shown to exhibit negative optical rotation and hence has the R-configuration.
G A, Ellestad, W, Swenson, W J, McGahren
openaire +3 more sources
Facile C1 Epimerization of α-1-Sulfonamidyl-2-deoxy-2-iodo- glycopyranosides [PDF]
, 2016 Facile C1 Epimerization of α-1-Sulfonamidyl-2-deoxy-2-iodo ...
Jane M. Owens (3026601) +3 more
core +1 more source
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source
Drug Testing and Analysis, EarlyView.A validated LC‐HRMS/MS method enabled the first quantitative determination of the LGD‐4033 long‐term metabolite (M5‐b) in urine following controlled micro‐dose administration. The generated urinary reference data support the interpretation of adverse analytical findings and anti‐doping result management. ABSTRACT Selective androgen receptor modulators (
Panagiotis Sakellariou +7 more
wiley +1 more source
Effect of cyclodextrins on the thermal epimerization of tea catechins [PDF]
The epimerization reaction of tea catechins was investigated at pH 5.5 and 120°C in the absence/presence of cyclodextrins (CDs). In the absence of CDs, a considerable quantity (∼20%) of products originating from reactions other than the epimerization ...
Ichitani, Masaki +3 more
core
Facile epimerization of (+)-sclareolide : A versatile experiment for laboratory education [PDF]
An experiment to teach the concept of epimerization in advanced practical settings is presented in a versatile format suitable for those interested in developing their laboratory curriculum and activities.
Lynch, Orla M. +11 more
core +1 more source