Results 111 to 120 of about 13,012 (246)

Fengycin or plipastatin? A confusing question in Bacilli

BioTechnologia, 2019
According to most of the related literature published since their discovery in 1986, fengycin and plipastatin are very related molecules. These are lipodecapeptides encoded by operons of five synthetase genes.
Walaa Hussein
doaj   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions [PDF]

Palladium-catalyzed cross-couplings remain among the most robust methodologies to form carbon–carbon and carbon-heteroatom bonds. In particular, carbon–nitrogen (C–N) couplings (Buchwald–Hartwig aminations) find widespread use in fine chemicals ...
Kurita, Kenji L., Derasp, Joshua S., Cai, Isabelle, Sirois, Lauren E., Malig, Thomas C., Hein, Jason Ellis   +5 more
core   +1 more source

Unveiling epimerization effects: a rotational study of alpha-D-galactose [PDF]

, 2015
By studying its C4 epimer alpha-D-galactose, the effects of epimerization on the conformational behaviour of alpha-D-glucose have been unveiled. Using laser ablation of crystalline samples, four conformers of alpha-D-galactopyranose have been observed,
Alonso Hernández, José Luis, Cabezas, Carlos, Peña Calvo, María Isabel   +2 more
core   +1 more source

Garner’s aldehyde as a versatile intermediate in the synthesis of enantiopure natural products

Beilstein Journal of Organic Chemistry, 2013
Since its introduction to the synthetic community in 1984, Garner’s aldehyde has gained substantial attention as a chiral intermediate for the synthesis of numerous amino alcohol derivatives.
Mikko Passiniemi, Ari M.P. Koskinen
doaj   +1 more source

Synthesis and Thermotropic Phase Behavior of Four Glycoglycerolipids

Molecules, 2013
Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller ...
Marité Cárdenas, Christian M. Pedersen, Vivien Jagalski, Mikael Bols, Thomas G. Pomorski, Wouter F. J. Hogendorf   +5 more
doaj   +1 more source

The gut microbiome organ

iMeta, EarlyView.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider, Claudia Hanko, Konrad Büssow, Stefan Schmelz, Wulf Blankenfeldt   +4 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source